R B Darnell
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Explore the profile of R B Darnell including associated specialties, affiliations and a list of published articles.
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44
Citations
3434
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Recent Articles
1.
Hwang J, Lee J, Oh C, Kang H, Hwang I, Um J, et al.
Cell Death Dis
. 2016 Jun;
7(6):e2240.
PMID: 27253404
Cerebellar degeneration-related protein 2 (cdr2) is expressed in the central nervous system, and its ectopic expression in tumor cells of patients with gynecological malignancies elicits immune responses by cdr2-specific autoantibodies...
2.
Darnell R
Cold Spring Harb Symp Quant Biol
. 2007 Mar;
71:321-7.
PMID: 17381312
Systematic dissection of the activity of RNA-binding proteins (RBPs) has begun to yield global insight into how they work. The paradigm we have used has been the study of Nova,...
3.
Darnell J, Mostovetsky O, Darnell R
Genes Brain Behav
. 2005 Aug;
4(6):341-9.
PMID: 16098133
The Fragile X Syndrome is caused by the loss of function of the FMR1 gene (Pieretti et al. 1991. Cell 66, 817-822; O'Donnell & Warren 2002. Annu Rev Neurosci 25,...
4.
Orange D, Jegathesan M, Blachere N, Frank M, Scher H, Albert M, et al.
Prostate Cancer Prostatic Dis
. 2004 Mar;
7(1):63-72.
PMID: 14999241
Despite the potency with which dendritic cells (DCs) are able to utilize the exogenous MHC I antigen cross-presentation pathway to cross-present antigen for the activation of killer T cells in...
5.
ODonovan K, Darnell R
Sci STKE
. 2001 Dec;
2001(94):pe2.
PMID: 11752670
Alternative splicing represents a mechanism by which a single gene can be used to create proteins with different functions. Neurons use alternative splicing to produce channels with different sequences and...
6.
Darnell J, Jensen K, Jin P, Brown V, Warren S, Darnell R
Cell
. 2001 Nov;
107(4):489-99.
PMID: 11719189
Loss of fragile X mental retardation protein (FMRP) function causes the fragile X mental retardation syndrome. FMRP harbors three RNA binding domains, associates with polysomes, and is thought to regulate...
7.
Brown V, Jin P, Ceman S, Darnell J, ODonnell W, Tenenbaum S, et al.
Cell
. 2001 Nov;
107(4):477-87.
PMID: 11719188
Fragile X syndrome results from the absence of the RNA binding FMR protein. Here, mRNA was coimmunoprecipitated with the FMRP ribonucleoprotein complex and used to interrogate microarrays. We identified 432...
8.
Albert M, Jegathesan M, Darnell R
Nat Immunol
. 2001 Oct;
2(11):1010-7.
PMID: 11590405
In vivo models have shown that tissue-restricted antigen may be captured by bone marrow-derived cells and cross-presented for the tolerization of CD8+ T cells. Although these studies have shown peripheral...
9.
Musunuru K, Darnell R
Annu Rev Neurosci
. 2001 Apr;
24:239-62.
PMID: 11283311
Studies of the disorders known as paraneoplastic neurologic degenerations exemplify the successful application of modern molecular biological techniques to diseases, yielding, even for these extremely rare disorders, wide-ranging insight into...
10.
Dredge B, Polydorides A, Darnell R
Nat Rev Neurosci
. 2001 Mar;
2(1):43-50.
PMID: 11253358
Splicing of pre-messenger RNA is regulated differently in the brain compared with other tissues. Recognition of aberrations in splicing events that are associated with neurological disease has contributed to our...