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R B Caldwell

Explore the profile of R B Caldwell including associated specialties, affiliations and a list of published articles. Areas
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Articles 69
Citations 1685
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Recent Articles
1.
Patel C, Xu Z, Shosha E, Xing J, Lucas R, Caldwell R, et al.
Biochim Biophys Acta . 2016 May; 1862(9):1628-39. PMID: 27239699
Retinal vascular injury is a major cause of vision impairment in ischemic retinopathies. Insults such as hyperoxia, oxidative stress and inflammation contribute to this pathology. Previously, we showed that hyperoxia-induced...
2.
Ha Y, Liu H, Xu Z, Yokota H, Narayanan S, Lemtalsi T, et al.
Cell Death Dis . 2015 Oct; 6:e1900. PMID: 26448323
Acute glaucoma is a leading cause of irreversible blindness in East Asia. The mechanisms underlying retinal neuronal injury induced by a sudden rise in intraocular pressure (IOP) remain obscure. Here...
3.
Narayanan S, Xu Z, Putluri N, Sreekumar A, Lemtalsi T, Caldwell R, et al.
Cell Death Dis . 2014 Feb; 5:e1075. PMID: 24556690
Hyperoxia treatment has been known to induce neuronal and glial death in the developing central nervous system. Retinopathy of prematurity (ROP) is a devastating disease in premature infants and a...
4.
HOERMAN K, MANCEWICZ S, BERZINSKAS V, Caldwell R
Res Summ (Nav Med Res Inst) . 2014 Feb; 42:1-5. PMID: 24547266
No abstract available.
5.
Elms S, Toque H, Rojas M, Xu Z, Caldwell R, Caldwell R
Diabetologia . 2012 Dec; 56(3):654-62. PMID: 23232640
Aims/hypothesis: A reduction in retinal blood flow occurs early in diabetes and is likely to be involved in the development of diabetic retinopathy. We hypothesise that activation of the arginase...
6.
Chandra S, Romero M, Shatanawi A, Alkilany A, Caldwell R, Caldwell R
Br J Pharmacol . 2011 Jul; 165(2):506-19. PMID: 21740411
Background And Purpose: NO produced by endothelial NOS is needed for normal vascular function. During diabetes, aging and hypertension, elevated levels of arginase can compete with NOS for available l-arginine,...
7.
Penn J, Madan A, Caldwell R, Bartoli M, Caldwell R, Hartnett M
Prog Retin Eye Res . 2008 Jul; 27(4):331-71. PMID: 18653375
Collectively, angiogenic ocular conditions represent the leading cause of irreversible vision loss in developed countries. In the US, for example, retinopathy of prematurity, diabetic retinopathy and age-related macular degeneration are...
8.
Bachl J, Caldwell R, Buerstedde J
Cytogenet Genome Res . 2007 Aug; 117(1-4):189-94. PMID: 17675859
Protein optimization is a major focus of the biotech and pharmaceutical industry. Various in vitro technologies have been developed to accelerate protein evolution and to achieve protein optimization of functional...
9.
Jin L, Caldwell R, Li-Masters T, Caldwell R
J Physiol Pharmacol . 2007 Jul; 58(2):191-206. PMID: 17622691
Hyperhomocysteinemia is an independent risk factor for cardiovascular diseases. High levels of plasma homocysteine (HCY) increase oxidative stress and reduce endothelial-dependent relaxation. We determined whether hyperhomocysteinemia-induced endothelial dysfunction is mediated...
10.
El-Remessy A, Al-Shabrawey M, Platt D, Bartoli M, Behzadian M, Ghaly N, et al.
FASEB J . 2007 Mar; 21(10):2528-39. PMID: 17384142
The modulation of angiogenic signaling by reactive oxygen species (ROS) is an emerging area of interest in cellular and vascular biology research. We provide evidence here that peroxynitrite, the powerful...