R A Olmsted
Overview
Explore the profile of R A Olmsted including associated specialties, affiliations and a list of published articles.
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Articles
40
Citations
1616
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Recent Articles
1.
Genin M, Poel T, May P, Kopta L, Yagi Y, Olmsted R, et al.
J Med Chem
. 1999 Oct;
42(20):4140-9.
PMID: 10514284
Development of resistance to currently approved HIV therapies has continued to fuel research efforts to improve the metabolic stability and spectrum of activity of the (alkylamino)piperidine-containing bis(heteroaryl)piperazine (AAP-BHAP) class of...
2.
Nugent R, Schlachter S, Murphy M, Cleek G, Poel T, Wishka D, et al.
J Med Chem
. 1998 Sep;
41(20):3793-803.
PMID: 9748354
A series of pyrimidine thioethers was synthesized and evaluated for inhibitory properties against wild-type HIV-1 reverse transcriptase (RT) and an RT carrying the resistance-conferring mutation P236L. Modifications of both the...
3.
Wishka D, Graber D, Kopta L, Olmsted R, Friis J, Hosley J, et al.
J Med Chem
. 1998 May;
41(9):1357-60.
PMID: 9554867
No abstract available.
4.
Genin M, Poel T, Yagi Y, Biles C, Althaus I, Keiser B, et al.
J Med Chem
. 1996 Dec;
39(26):5267-75.
PMID: 8978855
The major route of metabolism of the bis(heteroaryl)piperazine (BHAP) class of reverse transcriptase inhibitors (RTIs), atevirdine and delavirdine, is via oxidative N-dealkylation of the 3-ethyl- or 3-isopropylamino substituent on the...
5.
Romero D, Olmsted R, Poel T, Morge R, Biles C, Keiser B, et al.
J Med Chem
. 1996 Sep;
39(19):3769-89.
PMID: 8809165
A novel class of bis(heteroaryl)piperazine (BHAP) analogs which possesses the ability to inhibit NNRTI (non-nucleoside reverse transcriptase inhibitor) resistant recombinant HIV-1 reverse transcriptase (RT) and NNRTI resistant variants of HIV-1...
6.
Fan N, Rank K, Slade D, Poppe S, Evans D, Kopta L, et al.
Biochemistry
. 1996 Jul;
35(30):9737-45.
PMID: 8703945
Selection of the IIIB strain of human immunodeficiency virus type (HIV-1) resistant to the (alkylamino)piperidine-bis(heteroaryl)piperazine (AAP-BHAP) U-104489 results in substitution of a glycine to glutamate at residue 190 (G190E) of...
7.
Olmsted R, Slade D, Kopta L, Poppe S, Poel T, Newport S, et al.
J Virol
. 1996 Jun;
70(6):3698-705.
PMID: 8648704
The (alkylamino)piperidine bis(heteroaryl)piperizines (AAP-BHAPs) are a new class of human immunodeficiency virus type 1 (HIV-1)-specific inhibitors which were identified by targeted screening of recombinant reverse transcriptase (RT) enzymes carrying key...
8.
Langley R, Hirsch V, OBrien S, Goeken R, Olmsted R
Virology
. 1994 Aug;
202(2):853-64.
PMID: 8030248
The complete nucleotide sequence of an isolate of puma lentivirus (PLV-14) was obtained by an inverse polymerase chain reaction (I-PCR) technique and confirmed by conventional PCR. Both methods were used...
9.
Phillips T, Prospero-Garcia O, Puaoi D, Lerner D, Fox H, Olmsted R, et al.
J Gen Virol
. 1994 May;
75 ( Pt 5):979-87.
PMID: 8176384
Specific pathogen-free cats were infected with the Maryland strain of FIV (FIV-MD) for the purpose of assessing the effects of FIV infection on the central nervous system (CNS). Two separate...
10.
Homa F, Brideau R, Lehman D, Thomsen D, Olmsted R, Wathen M
J Gen Virol
. 1993 Sep;
74 ( Pt 9):1995-9.
PMID: 8397289
A cotton rat model of experimental human respiratory syncytial virus (RSV) and human parainfluenza virus type 3 (PIV-3) infection was used to examine the efficacy of FRHNP, a novel chimeric...