Qingchuan Zheng
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Explore the profile of Qingchuan Zheng including associated specialties, affiliations and a list of published articles.
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Articles
42
Citations
187
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Recent Articles
1.
Zhao X, Zhang H, Shen X, Zheng Q, Wang S
Int J Mol Sci
. 2025 Mar;
26(5).
PMID: 40076644
Heptachlor (HEP) is an insecticide metabolized by cytochrome P450 (CYP) enzymes in the human liver, resulting in the formation of heptachlor epoxide (HEPX). HEPX can persist in the human body...
2.
Zhang Y, Zheng Q, Warshel A, Bai C
J Am Chem Soc
. 2025 Jan;
147(4):3539-3552.
PMID: 39804793
The parathyroid hormone type 1 receptor (PTH1R) plays a crucial role in modulating various physiological functions and is considered an effective therapeutic target for osteoporosis. However, a lack of detailed...
3.
Xing G, Zheng Q
Phys Chem Chem Phys
. 2024 Aug;
26(34):22726-22738.
PMID: 39161312
Matrix protein 2 (M2) and matrix protein 1 (M1) of the influenza B virus are two important proteins, and the interactions between BM2 and BM1 play an important role in...
4.
Feng S, Zheng Q
J Hazard Mater
. 2024 Jun;
476:134933.
PMID: 38925058
7H-Dibenzo[c,g]carbazole (DBC) is a prevalent environmental contaminant that induces tumorigenesis in several experimental animals. Recently, it has been utilized to develop high-performance solar cells and organic phosphorescent materials. It is...
5.
Wu S, Zhou X, Li F, Sun W, Zheng Q, Liang D
Int J Mol Sci
. 2024 Mar;
25(6).
PMID: 38542320
In this study, we designed two series of novel anthraquinone-based benzenesulfonamide derivatives and their analogues as potential carbonic anhydrase inhibitors (CAIs) and evaluated their inhibitory activities against off-target human carbonic...
6.
Fu T, Zhang H, Zheng Q
Phys Chem Chem Phys
. 2024 Feb;
26(11):8807-8814.
PMID: 38421040
Cytochrome P450 3A4 (CYP3A4) is involved in the metabolism of more drugs in clinical use than any other xenobiotic-metabolizing enzyme. CYP3A4-mediated drug metabolism is usually allosterically modulated by substrate concentration...
7.
Liu A, Zhang H, Zheng Q, Wang S
Molecules
. 2024 Feb;
29(3).
PMID: 38338365
The influenza BM2 transmembrane domain (), an acid-activated proton channel, is an attractive antiviral target due to its essential roles during influenza virus replication, whereas no effective inhibitors have been...
8.
Liu S, Zheng Q, Bai F
Molecules
. 2023 Oct;
28(19).
PMID: 37836743
CYP 3A4 and CYP 3A5 are two important members of the human cytochrome P450 family. Although their overall structures are similar, the local structures of the active site are different,...
9.
Sun M, Lyu L, Zheng Q
Chem Res Toxicol
. 2023 Jul;
36(8):1313-1320.
PMID: 37468477
Caffeine is a very common kind of nervous stimulant, and it is primarily metabolized by Cytochrome P450 1A2 (CYP1A2) in the human body. Over the years, determining the interactions between...
10.
Zhang X, Li L, Zheng Q
J Chem Inf Model
. 2023 Jul;
63(15):4762-4771.
PMID: 37452749
Pf2001 esterase (Pf2001) from has hyperthermophilic properties and exerts a biocatalytic function in a dimeric state. Crystal structures revealed that the structural rearrangement of the cap domain is responsible for...