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Qiao-Qiao Min

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Articles 19
Citations 249
Followers 0
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Recent Articles
1.
Zhou M, Ren J, Feng X, Zhao H, Fu X, Min Q, et al.
Chem Sci . 2024 Feb; 15(8):2937-2945. PMID: 38404383
An efficient method for the late-stage selective -fluoroalkylation of tyrosine residues with a stable yet highly reactive fluoroalkylating reagent, 3,3-difluoroallyl sulfonium salts (DFASs), has been developed. The reaction proceeds in...
2.
Zhang X, Sun S, Sang Y, Xue X, Min Q, Zhang X
Angew Chem Int Ed Engl . 2023 Jun; 62(37):e202306501. PMID: 37365143
A palladium-catalyzed reductive difluorocarbene transfer reaction that tames difluorocarbene to couple with two electrophiles has been developed, representing a new mode of difluorocarbene transfer reaction. The approach uses low-cost and...
3.
Zeng X, Li Y, Min Q, Xue X, Zhang X
Nat Chem . 2023 Jun; 15(8):1064-1073. PMID: 37308708
The use of metal catalysts to produce and control the reactivity of carbenes has long offered a powerful approach to organic synthesis; however, difluorocarbene transfer catalysed by metal is an...
4.
Feng X, Ren J, Gao X, Min Q, Zhang X
Angew Chem Int Ed Engl . 2022 Aug; 61(42):e202210103. PMID: 36042013
The site-selective introduction of the difluoromethylene group into organic molecules has important applications in producing pharmaceuticals and agrochemicals. However, the general and efficient methods that can construct both C(sp )-CF...
5.
Ren X, Gao X, Min Q, Zhang S, Zhang X
Chem Sci . 2022 Apr; 13(12):3454-3460. PMID: 35432852
Difluoroalkylated compounds have important applications in pharmaceutical, agrochemical, and materials science. However, efficient methods to construct the alkylCF-alkyl bond are very limited, and the site-selective introduction of a difluoromethylene (CF)...
6.
Zhang D, Gao X, Min Q, Gu Y, Berthon G, Zhang X
Chemistry . 2022 Mar; 28(26):e202200642. PMID: 35238111
A nickel-catalyzed cross-coupling of heteroaryl halides with chlorodifluoroacetamides and chlorodifluoroacetate has been developed. The combination of NiCl  ⋅ DME with 4,4'-diNon-bpy, co-ligand PPh , and additive LiCl renders the catalytic...
7.
Song H, Cheng R, Min Q, Zhang X
Org Lett . 2020 Sep; 22(19):7747-7751. PMID: 32946242
A general method for site-selective difluoroalkylation of alkyl carboxylic redox esters with difluoroenoxysilanes through photoredox-catalyzed decarboxylative reaction has been developed. The reaction can also be extended to aliphatic amine derived...
8.
Feng Z, Min Q, Fu X, An L, Zhang X
Nat Chem . 2017 Aug; 9(9):918-923. PMID: 28837166
Difluoromethylated aromatic compounds are of increasing importance in pharmaceuticals, agrochemicals and materials. Chlorodifluoromethane (ClCFH), an inexpensive, abundant and widely used industrial raw material, represents the ideal and most straightforward difluoromethylating...
9.
Gu J, Min Q, Yu L, Zhang X
Angew Chem Int Ed Engl . 2016 Sep; 55(40):12270-4. PMID: 27605485
A nickel-catalyzed three-component reaction for the synthesis of difluoroalkylated compounds through tandem difluoroalkylation-arylation of enamides has been developed. The reaction tolerates a variety of arylboronic acids and widely available difluoroalkyl...
10.
Xiao Y, Min Q, Xu C, Wang R, Zhang X
Angew Chem Int Ed Engl . 2016 Apr; 55(19):5837-41. PMID: 27060704
A nickel-catalyzed cross-coupling between (hetero)arylborons and unactivated 1-bromo-1,1-difluoroalkanes has been developed. The use of two ligands (a bidentate bipyridine-based ligand, 4,4'-ditBu-bpy, and a monodentate pyridine-based ligand, DMAP) offers a highly...