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Qiansen Zhang

Explore the profile of Qiansen Zhang including associated specialties, affiliations and a list of published articles. Areas
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Articles 39
Citations 404
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Recent Articles
1.
He J, Chai X, Zhang Q, Wang Y, Wang Y, Yang X, et al.
Nat Immunol . 2025 Mar; PMID: 40065162
No abstract available.
2.
Wu J, Wang L, Sun Y, Lv S, Wu J, Zheng L, et al.
Int J Biol Macromol . 2025 Mar; :141580. PMID: 40023413
Protein-Glutaminase (PG) with efficient deamidation ability has shown vital potential in food fields. Enzymes with high thermostability remain active in high-temperature environments, which can be applied to some steps requiring...
3.
He J, Chai X, Zhang Q, Wang Y, Wang Y, Yang X, et al.
Nat Immunol . 2025 Feb; 26(3):391-403. PMID: 39905201
Most patients with colorectal cancer do not achieve durable clinical benefits from immunotherapy, underscoring the existence of alternative immunosuppressive mechanisms. Here we found that activation of the lactate receptor HCAR1...
4.
Li J, Yang Z, Zhang S, Ye Y, He J, Zhang Y, et al.
Nat Chem Biol . 2025 Jan; PMID: 39814994
Voltage-gated ion channels (VGICs) are crucial targets for neuropsychiatric therapeutics owing to their role in controlling neuronal excitability and the established link between their dysfunction and neurological diseases, highlighting the...
5.
Lin H, Li J, Zhang Q, Yang H, Chen S
Proc Natl Acad Sci U S A . 2024 Apr; 121(17):e2320345121. PMID: 38630723
The TWIK-related acid-sensitive K channel 3 (TASK3) belongs to the two-pore domain (K2P) potassium channel family, which regulates cell excitability by mediating a constitutive "leak" potassium efflux in the nervous...
6.
Chen H, Bian A, Zhou W, Miao Y, Ye J, Li J, et al.
ACS Cent Sci . 2024 Apr; 10(3):579-594. PMID: 38559310
Signal transducer and activator of transcription 3 (STAT3) is an attractive cancer therapeutic target. Unfortunately, targeting STAT3 with small molecules has proven to be very challenging, and for full activation...
7.
Weng Y, Yang X, Zhang Q, Chen Y, Xu Y, Zhu C, et al.
Sci China Life Sci . 2024 Feb; 67(5):986-995. PMID: 38319473
The adenosine subfamily G protein-coupled receptors AR and AR have been identified as promising cancer immunotherapy candidates. One of the AR/AR dual antagonists, AB928, has progressed to a phase II...
8.
Zhang S, Ma D, Wang K, Li Y, Yang Z, Li X, et al.
Nat Chem Biol . 2024 Jan; 20(7):847-856. PMID: 38167918
Pharmacological activation of voltage-gated ion channels by ligands serves as the basis for therapy and mainly involves a classic gating mechanism that augments the native voltage-dependent open probability. Through structure-based...
9.
Liu H, Polovitskaya M, Yang L, Li M, Li H, Han Z, et al.
Cell Rep . 2023 Aug; 42(8):112926. PMID: 37543949
Volume-regulated anion channels (VRACs) are hexamers of LRRC8 proteins that are crucial for cell volume regulation. N termini (NTs) of the obligatory LRRC8A subunit modulate VRACs activation and ion selectivity,...
10.
Cheng Z, Wang Y, Zhang Y, Zhang C, Wang M, Wang W, et al.
J Med Chem . 2023 Mar; 66(9):6218-6238. PMID: 36880691
Nowadays, small-molecule drugs have become an indispensable part of tumor immunotherapy. Accumulating evidence has indicated that specifically blocking PGE/EP4 signaling to induce robust antitumor immune response represents an attractive immunotherapy...