Pyung-Gang Lee
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Explore the profile of Pyung-Gang Lee including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
152
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Recent Articles
1.
Martinez-Carranza M, Skerlova J, Lee P, Zhang J, Krc A, Sirohiwal A, et al.
Commun Chem
. 2024 Aug;
7(1):179.
PMID: 39138288
Botulinum neurotoxins (BoNTs) are the most potent toxins known and are used to treat an increasing number of medical disorders. All BoNTs are naturally co-expressed with a protective partner protein...
2.
Manion J, Musser M, Kuziel G, Liu M, Shepherd A, Wang S, et al.
Nature
. 2023 Sep;
622(7983):611-618.
PMID: 37699522
Clostridioides difficile infection (CDI) is a major cause of healthcare-associated gastrointestinal infections. The exaggerated colonic inflammation caused by C. difficile toxins such as toxin B (TcdB) damages tissues and promotes...
3.
Hodgins H, Chen P, Lobb B, Wei X, Tremblay B, Mansfield M, et al.
Nat Commun
. 2023 Sep;
14(1):5475.
PMID: 37673908
The analysis of microbial genomes from human archaeological samples offers a historic snapshot of ancient pathogens and provides insights into the origins of modern infectious diseases. Here, we analyze metagenomic...
4.
Liu Z, Lee P, Krez N, Lam K, Liu H, Przykopanski A, et al.
Nat Commun
. 2023 Apr;
14(1):2338.
PMID: 37095076
Botulinum neurotoxin E (BoNT/E) is one of the major causes of human botulism and paradoxically also a promising therapeutic agent. Here we determined the co-crystal structures of the receptor-binding domain...
5.
Martinez-Carranza M, Skerlova J, Lee P, Zhang J, Burgin D, Elliott M, et al.
bioRxiv
. 2023 Jan;
PMID: 36712025
Botulinum neurotoxins (BoNTs) are the most potent toxins known and are used to treat an increasing number of medical disorders. All BoNTs are naturally co-expressed with a protective partner protein...
6.
Fang Y, Chang A, Verma D, Miyashita S, Eszterhas S, Lee P, et al.
ACS Synth Biol
. 2023 Jan;
12(1):153-163.
PMID: 36623275
Botulinum neurotoxin serotype A (BoNT/A) is a widely used cosmetic agent that also has diverse therapeutic applications; however, adverse antidrug immune responses and associated loss of efficacy have been reported...
7.
Song H, Lee P, Kim J, Kim J, Lee S, Kim H, et al.
Front Bioeng Biotechnol
. 2022 Apr;
10:830712.
PMID: 35402392
Several regiospecific enantiomers of hydroxy-()-equol (HE) were enzymatically synthesized from daidzein and genistein using consecutive reduction (four daidzein-to-equol-converting reductases) and oxidation (4-hydroxyphenylacetate 3-monooxygenase, HpaBC). Despite the natural occurrence of several...
8.
Lee U, Ko J, Kim S, Lee P, An Y, Yun H, et al.
Adv Sci (Weinh)
. 2022 Jan;
9(7):e2103503.
PMID: 34989175
Tyrosinase-mediated melanin synthesis is an essential biological process that can protect skin from UV radiation and radical species. This work reports on in situ biosynthesis of artificial melanin in native...
9.
Song H, Lee P, Kim H, Lee U, Lee S, Kim J, et al.
Microorganisms
. 2021 Sep;
9(9).
PMID: 34576760
Tyrosinase is generally known as a melanin-forming enzyme, facilitating monooxygenation of phenols, oxidation of catechols into quinones, and finally generating biological melanin. As a homologous form of tyrosinase in plants,...
10.
Blum T, Liu H, Packer M, Xiong X, Lee P, Zhang S, et al.
Science
. 2021 Feb;
371(6531):803-810.
PMID: 33602850
Although bespoke, sequence-specific proteases have the potential to advance biotechnology and medicine, generation of proteases with tailor-made cleavage specificities remains a major challenge. We developed a phage-assisted protease evolution system...