Pushpamali De Silva
Overview
Explore the profile of Pushpamali De Silva including associated specialties, affiliations and a list of published articles.
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30
Citations
654
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Recent Articles
1.
De Silva P, Saad M, Swain J, Mai Z, Kidd M, Choe J, et al.
J Photochem Photobiol B
. 2025 Feb;
265:113126.
PMID: 40007355
The poor response of pancreatic ductal adenocarcinoma (PDAC) to treatment, including immunotherapy, is attributed to its tumor microenvironment (TME). An ongoing challenge is the desmoplastic and immunosuppressed TME that evades...
2.
Spisak S, Chen D, Likasitwatanakul P, Doan P, Li Z, Bala P, et al.
Nat Commun
. 2024 Mar;
15(1):2230.
PMID: 38472198
Aberrant stem cell-like activity and impaired differentiation are central to the development of colorectal cancer (CRC). To identify functional mediators of these key cellular programs, we engineer a dual endogenous...
3.
Senevirathne T, Wekking D, Swain J, Solinas C, De Silva P
Cytokine Growth Factor Rev
. 2023 Dec;
76:127-141.
PMID: 38135574
The vigorous spread of SARS-CoV-2 resulted in the rapid infection of millions of people worldwide and devastation of not only public healthcare, but also social, educational, and economic infrastructures. The...
4.
Wekking D, Senevirathne T, Pearce J, Aiello M, Scartozzi M, Lambertini M, et al.
Cytokine Growth Factor Rev
. 2023 Dec;
75:110-118.
PMID: 38103990
The COVID-19 pandemic poses a significant challenge for individuals with compromised immune systems, such as patients with cancer, as they face a heightened susceptibility to severe infections compared to the...
5.
De Silva P, Bano S, Pogue B, Wang K, Maytin E, Hasan T
Nanophotonics
. 2023 Jul;
10(12):3199-3214.
PMID: 37485044
Photodynamic priming (), a collateral effect of photodynamic therapy, can transiently alter the tumor microenvironment (TME) beyond the cytotoxic zone. Studies have demonstrated that increases tumor permeability and modulates immune-stimulatory...
6.
De Silva P, Saad M, Thomsen H, Bano S, Ashraf S, Hasan T
J Porphyr Phthalocyanines
. 2023 Jul;
24(11n12):1320-1360.
PMID: 37425217
Photodynamic therapy is a photochemistry-based approach, approved for the treatment of several malignant and non-malignant pathologies. It relies on the use of a non-toxic, light activatable chemical, photosensitizer, which preferentially...
7.
Wekking D, Porcu M, De Silva P, Saba L, Scartozzi M, Solinas C
Curr Oncol Rep
. 2023 Feb;
25(4):257-267.
PMID: 36749493
Purpose Of Review: This article aims to provide an updated overview of the indications for diagnostic breast magnetic resonance imaging (MRI), discusses the available and novel imaging exams proposed for...
8.
Petrelli F, Bertaglia V, Parati M, Borgonovo K, De Silva P, Luciani A, et al.
Breast
. 2022 Dec;
67:8-13.
PMID: 36549170
The current standard of care for resected early-stage triple negative breast cancer (TNBC) patients who did not receive systemic preoperative therapy is adjuvant anthracycline- and taxane-based chemotherapy (CT). A network...
9.
Anand S, Heusinkveld L, Cheng C, Lefatshe L, De Silva P, Hasan T, et al.
Photochem Photobiol
. 2022 Aug;
99(2):437-447.
PMID: 36039609
We previously showed that a combination of differentiation-inducing agents (5-fluorouracil [5FU], vitamin D3 or methotrexate) and aminolevulinate-based photodynamic therapy (PDT) improves clinical responses by enhancing protoporphyrin IX (PpIX) photosensitizer levels...
10.
Cau R, Solinas C, De Silva P, Lambertini M, Agostinetto E, Scartozzi M, et al.
Int J Cancer
. 2022 Jun;
151(11):1860-1873.
PMID: 35730658
Immune checkpoint inhibitor (ICI)-induced cardiotoxicity is a rare immune-related adverse event (irAE) characterized by a high mortality rate. From a pathological point of view, this condition can result from a...