Purushoth Ethiraj
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Explore the profile of Purushoth Ethiraj including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
116
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Recent Articles
1.
Duque A, Ferrari P, Ethiraj P, Jaafar C, Qiu Z, Holder K, et al.
Cancers (Basel)
. 2024 Nov;
16(22.
PMID: 39594812
Background: Diffuse large B-cell lymphoma (DLBCL) is a common and often fatal malignancy. The standard-of-care immunochemotherapy, R-CHOP, cures only about 60% of DLBCL patients. Improving this cure rate will likely...
2.
Qiu Z, Khalife J, Ethiraj P, Jaafar C, Lin A, Holder K, et al.
Sci Adv
. 2024 Jul;
10(28):eadk2091.
PMID: 38996030
The mechanism by which interferon regulatory factor 8 (IRF8) mutation contributes to lymphomagenesis is unknown. We modeled IRF8 variants in B cell lymphomas and found that they affected the expression...
3.
Qiu Z, Khalife J, Lin A, Ethiraj P, Jaafar C, Chiou L, et al.
bioRxiv
. 2023 Oct;
PMID: 37873241
In diffuse large B-cell lymphoma (DLBCL), the transcription factor IRF8 is the target of a series of potentially oncogenic events, including, chromosomal translocation, focal amplification, and super-enhancer perturbations. IRF8 is...
4.
Guo Q, Cheng Z, Gonzalez-Cantu H, Rotondi M, Huelgas-Morales G, Ethiraj P, et al.
Cell Rep
. 2023 Sep;
42(9):113070.
PMID: 37659079
The TMEM127 gene encodes a transmembrane protein of poorly known function that is mutated in pheochromocytomas, neural crest-derived tumors of adrenomedullary cells. Here, we report that, at single-nucleus resolution, TMEM127-mutant...
5.
Estrada-Zuniga C, Cheng Z, Ethiraj P, Guo Q, Gonzalez-Cantu H, Adderley E, et al.
Cell Rep Med
. 2022 Jul;
3(7):100686.
PMID: 35858593
The RET kinase receptor is a target of mutations in neural crest tumors, including pheochromocytomas, and of oncogenic fusions in epithelial cancers. We report a RET::GRB2 fusion in a pheochromocytoma...
6.
Ethiraj P, Sasi B, Holder K, Lin A, Qiu Z, Jaafar C, et al.
Br J Haematol
. 2022 Apr;
198(2):349-359.
PMID: 35411936
Angiogenesis and MYC expression associate with poor outcome in diffuse large B-cell lymphoma (DLBCL). MYC promotes neo-vasculature development but whether its deregulation in DLBCL contributes to angiogenesis is unclear. Examination...
7.
Lin A, Qiu Z, Ethiraj P, Sasi B, Jaafar C, Rakheja D, et al.
Leukemia
. 2022 Jan;
36(4):1150-1159.
PMID: 34997181
Mitochondria can function as signaling organelles, and part of this output leads to epigenetic remodeling. The full extent of this far-reaching interplay remains undefined. Here, we show that MYC transcriptionally...
8.
Ethiraj P, Haque I, Alford A, Gou W, Singh T, Sambandam Y, et al.
J Cell Biochem
. 2021 Jul;
122(10):1534-1543.
PMID: 34228377
We have recently demonstrated NFAT activating protein with ITAM motif 1 (NFAM1) signaling increases osteoclast (OCL) formation/bone resorption associated with the Paget's disease of bone, however, the underlying molecular mechanisms...
9.
Sasi B, Ethiraj P, Myers J, Lin A, Jiang S, Qiu Z, et al.
Leukemia
. 2020 Dec;
35(7):1990-2001.
PMID: 33299141
Cyclic-AMP (cAMP) exerts suppressive effects in the innate and adaptive immune system. The PD-1/PD-L1 immune checkpoint downregulates T-cell activity. Here, we examined if these two immunosuppressive nodes intersect. Using normal...
10.
Ethiraj P, Ottinger A, Singh T, Singh A, Haire K, Reddy S
Cytokine
. 2019 Aug;
125:154821.
PMID: 31470364
Microgravity (µXg) induces bone loss in astronauts during space missions. Therefore, it is necessary to delineate the underlying mechanisms which leads to bone loss for developing countermeasures. Osteoclasts (OCLs) are...