Prescott T Leach
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Explore the profile of Prescott T Leach including associated specialties, affiliations and a list of published articles.
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16
Citations
385
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Recent Articles
1.
Kazdoba T, Leach P, Yang M, Silverman J, Solomon M, Crawley J
Curr Top Behav Neurosci
. 2016 Jun;
28:1-52.
PMID: 27305922
Animal models provide preclinical tools to investigate the causal role of genetic mutations and environmental factors in the etiology of autism spectrum disorder (ASD). Knockout and humanized knock-in mice, and...
2.
Leach P, Kenney J, Gould T
Neurosci Lett
. 2016 May;
627:61-4.
PMID: 27235579
Acute nicotine enhances hippocampus-dependent learning. Identifying how acute nicotine improves learning will aid in understanding how nicotine facilitates the development of maladaptive memories that contribute to drug-seeking behaviors, help development...
3.
Normal Performance of Fmr1 Mice on a Touchscreen Delayed Nonmatching to Position Working Memory Task
Leach P, Hayes J, Pride M, Silverman J, Crawley J
eNeuro
. 2016 Mar;
3(1).
PMID: 27022628
Fragile X syndrome is a neurodevelopmental disorder characterized by mild-to-severe cognitive deficits. The complete absence of Fmr1 and its protein product in the mouse model of fragile X (Fmr1 KO)...
4.
Mandal M, Wu Y, Misiaszek J, Li G, Buevich A, Caldwell J, et al.
J Med Chem
. 2016 Mar;
59(7):3231-48.
PMID: 26937601
We describe successful efforts to optimize the in vivo profile and address off-target liabilities of a series of BACE1 inhibitors represented by 6 that embodies the recently validated fused pyrrolidine...
5.
Leach P, Gould T
Neurosci Biobehav Rev
. 2015 Sep;
57:252-63.
PMID: 26344666
Cigarette smoking is common despite its adverse effects on health, such as cardiovascular disease and stroke. Understanding the mechanisms that contribute to the addictive properties of nicotine makes it possible...
6.
Leach P, Kenney J, Connor D, Gould T
Neuropharmacology
. 2015 Feb;
93:155-63.
PMID: 25666034
Cigarette smoking is common despite adverse health effects. Nicotine's effects on learning may contribute to addiction by enhancing drug-context associations. Effects of nicotine on learning could be direct or could...
7.
Kazdoba T, Leach P, Silverman J, Crawley J
Intractable Rare Dis Res
. 2015 Jan;
3(4):118-33.
PMID: 25606362
Fragile X Syndrome (FXS) is a commonly inherited form of intellectual disability and one of the leading genetic causes for autism spectrum disorder. Clinical symptoms of FXS can include impaired...
8.
Leach P, Kenney J, Gould T
Neurobiol Learn Mem
. 2014 Dec;
118:162-6.
PMID: 25543025
Increased training often results in stronger memories but the neural changes responsible for these stronger memories are poorly understood. It is proposed here that higher levels of training that result...
9.
Leach P, Holliday E, Kutlu M, Gould T
Nicotine Tob Res
. 2014 Nov;
17(6):690-6.
PMID: 25358661
Introduction: Cigarette smoking alters a variety of endocrine systems including thyroid hormones. Altered thyroid hormone signaling may lead to a subclinical or overt hypothyroid condition that could contribute to nicotine...
10.
Gould T, Wilkinson D, Yildirim E, Poole R, Leach P, Simmons S
Neurobiol Learn Mem
. 2014 Jan;
109:151-9.
PMID: 24457151
Acute nicotine enhances hippocampus-dependent learning through nicotine binding to β2-containing nicotinic acetylcholine receptors (nAChRs), but it is unclear if nicotine is targeting processes involved in short-term memory (STM) leading to...