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» Authors » Prashasti Sinha

Prashasti Sinha

Explore the profile of Prashasti Sinha including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 1
Followers 0
Related Specialties
Molecular Biology
Biochemistry
Co-Authors
Anil Kumar Yadav
Published In
J Biomol Struct Dyn
J Mol Model
Mol Divers
Affiliations
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Recent Articles
1.
Unraveling the anti-breast cancer activity of Cimicifugae rhizoma using biological network pathways and molecular dynamics simulation
Sinha P, Yadav A
Mol Divers . 2024 Apr; 29(1):241-254. PMID: 38615110
Cimicifugae is a commonly used treatment for breast cancer, but the specific molecular mechanisms underlying its effectiveness remain unclear. In this research, we employ a combination of network pharmacology, molecular...
2.
Repurposing integrase inhibitors against human T-lymphotropic virus type-1: a computational approach
Sinha P, Yadav A
J Biomol Struct Dyn . 2024 Jan; :1-12. PMID: 38234060
Adult T-cell Lymphoma (ATL) is caused by the delta retrovirus family member known as Human T-cell Leukaemia Type I (HTLV-1). Due to the unavailability of any cure, the study gained...
3.
Molecular docking, molecular dynamics and binding free energy based identification of novel potential multitarget inhibitors of Nipah virus
Sinha P, Yadav A
J Biomol Struct Dyn . 2023 Nov; 42(24):13663-13679. PMID: 37921740
Nipah virus (NiV) is one of the most common viral diseases affecting the brain and nervous system of the body. To date, there is no significant antiviral drug specifically designed...
4.
Identification of 3, 4-dihydroxy complexes as potential antiviral via DFT, molecular docking, molecular dynamics and MM/PBSA against rabies and dengue receptors
Sinha P, Yadav A
J Biomol Struct Dyn . 2023 Aug; 42(13):7037-7053. PMID: 37580968
The quest to identify antiviral drug candidates for dengue and rabies viral diseases is a great challenge for the researchers. While different research is being conducted on the repurposed drugs...
5.
identification of cyclosporin derivatives as potential inhibitors for RdRp of rotavirus by molecular docking and molecular dynamic studies
Sinha P, Yadav A
J Biomol Struct Dyn . 2023 Jul; 42(10):5001-5014. PMID: 37517053
Rotavirus is one of the most common gastrointestinal viral diseases. Till date, there are only two vaccines available in the markets, which are specifically to be administered to young babies....
6.
In silico identification and molecular dynamic simulations of derivatives of 6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide against main protease 3CL of SARS-CoV-2 viral infection
Sinha P, Yadav A
J Mol Model . 2023 Apr; 29(5):130. PMID: 37017775
Context: The unavailability of target-specific antiviral drugs for SARS-CoV-2 viral infection kindled the motivation to virtually design derivatives of 6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide as potential antiviral inhibitors against the concerned virus. The molecular...
7.
Identification of novel potential inhibitor of thymidylate kinase from Variola virus
Sinha P, Yadav A
J Biomol Struct Dyn . 2023 Mar; 41(23):14092-14102. PMID: 36907647
A hit compound was designed using Fragment Based Drug Designing (FBDD) approach, density functional theory (DFT) calculations were performed to find the structural and electronic properties. Additionally, pharmacokinetic properties were...