Prasad Kasturi
Overview
Explore the profile of Prasad Kasturi including associated specialties, affiliations and a list of published articles.
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11
Citations
1083
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Recent Articles
1.
Bhunia P, Raj V, Kasturi P
Mech Ageing Dev
. 2024 Nov;
222:112003.
PMID: 39505117
Proteome integrity is vital for survival and failure to maintain it results in uncontrolled protein abundances, misfolding and aggregation which cause proteotoxicity. In multicellular organisms, proteotoxic stress is communicated among...
2.
Panda P, Sarohi V, Basak T, Kasturi P
Cell Mol Neurobiol
. 2023 Dec;
44(1):3.
PMID: 38102300
Huntington's disease (HD) is one of the prominent neurodegenerative diseases, characterized by the progressive decline of neuronal function, due to the accumulation and aggregation of misfolded proteins. Pathological progression of...
3.
Muller M, Kasturi P, Jayaraj G, Hartl F
Cell
. 2023 Jun;
186(15):3227-3244.e20.
PMID: 37339632
Readthrough into the 3' untranslated region (3' UTR) of the mRNA results in the production of aberrant proteins. Metazoans efficiently clear readthrough proteins, but the underlying mechanisms remain unknown. Here,...
4.
Mukherjee P, Panda P, Kasturi P
Cell Stress Chaperones
. 2022 Sep;
27(6):619-631.
PMID: 36169889
Proteome imbalance can lead to protein misfolding and aggregation which is associated with pathologies. Protein aggregation can also be an active, organized process and can be exploited by cells as...
5.
Hipp M, Kasturi P, Hartl F
Nat Rev Mol Cell Biol
. 2019 Feb;
20(7):421-435.
PMID: 30733602
Ageing is a major risk factor for the development of many diseases, prominently including neurodegenerative disorders such as Alzheimer disease and Parkinson disease. A hallmark of many age-related diseases is...
6.
Walther D, Kasturi P, Zheng M, Pinkert S, Vecchi G, Ciryam P, et al.
Cell
. 2017 Feb;
168(5):944.
PMID: 28235202
No abstract available.
7.
Kirstein J, Morito D, Kakihana T, Sugihara M, Minnen A, Hipp M, et al.
EMBO J
. 2015 Aug;
34(18):2334-49.
PMID: 26228940
The cellular proteostasis network integrates the protein folding and clearance machineries in multiple sub-cellular compartments of the eukaryotic cell. The endoplasmic reticulum (ER) is the site of synthesis and folding...
8.
Walther D, Kasturi P, Zheng M, Pinkert S, Vecchi G, Ciryam P, et al.
Cell
. 2015 May;
161(4):919-32.
PMID: 25957690
Aging has been associated with a progressive decline of proteostasis, but how this process affects proteome composition remains largely unexplored. Here, we profiled more than 5,000 proteins along the lifespan...
9.
Gupta R, Kasturi P, Bracher A, Loew C, Zheng M, Villella A, et al.
Nat Methods
. 2011 Sep;
8(10):879-84.
PMID: 21892152
Maintenance of cellular protein homeostasis (proteostasis) depends on a complex network of molecular chaperones, proteases and other regulatory factors. Proteostasis deficiency develops during normal aging and predisposes individuals for many...
10.
Mouchiroud L, Molin L, Kasturi P, Triba M, Dumas M, Wilson M, et al.
Aging Cell
. 2010 Nov;
10(1):39-54.
PMID: 21040400
Dietary restriction (DR) is the most universal intervention known to extend animal lifespan. DR also prevents tumor development in mammals, and this effect requires the tumor suppressor PTEN. However, the...