Prakash Kharel
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Explore the profile of Prakash Kharel including associated specialties, affiliations and a list of published articles.
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26
Citations
935
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Recent Articles
1.
Kharel P
Methods Enzymol
. 2025 Feb;
711:47-63.
PMID: 39952717
Transfer RNA (tRNA)-derived small RNAs (tDRs) are emerging as a novel class of regulatory molecules with significant implications in gene expression and cellular processes. These tDRs are generated through precise...
2.
Kharel P, Bhatter N, Zubair S, Lyons S, Anderson P, Ivanov P
bioRxiv
. 2024 Dec;
PMID: 39651178
Guanine-rich nucleic acid sequences can exert sequence and/or structure specific activities to influence biological and pathobiological cellular processes. As such, it has been reported that different G-rich oligonucleotides (both DNA...
3.
Deforzh E, Kharel P, Zhang Y, Karelin A, El Khayari A, Ivanov P, et al.
Mol Cell
. 2024 Oct;
84(20):3950-3966.e6.
PMID: 39383879
The role of long non-coding RNAs (lncRNAs) in malignant cell transformation remains elusive. We previously identified an enhancer-associated lncRNA, LINC01116 (named HOXDeRNA), as a transformative factor converting human astrocytes into...
4.
Kharel P, Ivanov P
Mol Cell
. 2024 Oct;
84(19):3574-3575.
PMID: 39366344
In this issue of Molecular Cell, Anastasakis et al. describe a novel function of the metabolic enzyme PKM2 as an RNA G-quadruplex binding protein, which could contribute to cancer biology.
5.
Anabtawi N, Pasala M, Grimshaw A, Kharel P, Bal S, Godby K, et al.
J Cachexia Sarcopenia Muscle
. 2024 Apr;
15(3):1084-1093.
PMID: 38558541
Background: Low skeletal muscle mass (LSMM) and/or, function associated with an increased risk of treatment-related toxicities and inferior overall survival (OS) among adults with solid malignancies. However, the association between...
6.
Kharel P, Ivanov P
Methods Enzymol
. 2024 Mar;
695:255-274.
PMID: 38521588
RNAs often accomplish their diverse functions through direct interactions with RNA-binding proteins (RBPs) in a sequence- and/or structure-dependent manner. RNA G-quadruplexes (rG4s) are unique secondary structures formed by guanine-rich RNA...
7.
Kharel P, Ivanov P
Trends Cell Biol
. 2024 Feb;
34(9):771-784.
PMID: 38341346
RNA G-quadruplexes (rG4s) are noncanonical secondary structures formed by guanine-rich sequences that are found in different regions of RNA molecules. These structures have been implicated in diverse biological processes, including...
8.
Deforzh E, Kharel P, Karelin A, Ivanov P, Krichevsky A
bioRxiv
. 2023 Jul;
PMID: 37425921
Background: The origin and genesis of highly malignant and heterogenous glioblastoma brain tumors remain unknown. We previously identified an enhancer-associated long non-coding RNA, LINC01116 (named HOXDeRNA here), that is absent...
9.
Kharel P, Singhal N, Mahendran T, West N, Croos B, Rana J, et al.
Cell Chem Biol
. 2023 Mar;
30(3):308-320.e5.
PMID: 36882060
RNA oxidation has been implicated in neurodegeneration, but the underlying mechanism for such effects is unclear. Extensive RNA oxidation occurs within the neurons in multiple sclerosis (MS) brains. Here, we...
10.
Kharel P, Fay M, Manasova E, Anderson P, Kurkin A, Guo J, et al.
Nat Commun
. 2023 Jan;
14(1):205.
PMID: 36639366
Guanine (G)-rich nucleic acids can fold into G-quadruplex (G4) structures under permissive conditions. Although many RNAs contain sequences that fold into RNA G4s (rG4s) in vitro, their folding and functions...