Pontus Fischer
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Explore the profile of Pontus Fischer including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
474
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Recent Articles
1.
Lahey-Rudolph J, Schonherr R, Barthelmess M, Fischer P, Seuring C, Wagner A, et al.
IUCrJ
. 2021 Jul;
8(Pt 4):665-677.
PMID: 34258014
The crystallization of recombinant proteins in living cells is an exciting new approach in structural biology. Recent success has highlighted the need for fast and efficient diffraction data collection, optimally...
2.
Gunther S, Reinke P, Fernandez-Garcia Y, Lieske J, Lane T, Ginn H, et al.
Science
. 2021 Apr;
372(6542):642-646.
PMID: 33811162
The coronavirus disease (COVID-19) caused by SARS-CoV-2 is creating tremendous human suffering. To date, no effective drug is available to directly treat the disease. In a search for a drug...
3.
Stachnik K, Warmer M, Mohacsi I, Hennicke V, Fischer P, Meyer J, et al.
Sci Rep
. 2020 Feb;
10(1):1784.
PMID: 32019946
Studies of biological systems typically require the application of several complementary methods able to yield statistically-relevant results at a unique level of sensitivity. Combined X-ray fluorescence and ptychography offer excellent...
4.
Trachman 3rd R, Stagno J, Conrad C, Jones C, Fischer P, Meents A, et al.
Acta Crystallogr F Struct Biol Commun
. 2019 Aug;
75(Pt 8):547-551.
PMID: 31397326
Turn-on aptamers are in vitro-selected RNAs that bind to conditionally fluorescent small molecules and enhance their fluorescence. Upon binding TO1-biotin, the iMango-III aptamer achieves the largest fluorescence enhancement reported for...
5.
Lieske J, Cerv M, Kreida S, Komadina D, Fischer J, Barthelmess M, et al.
IUCrJ
. 2019 Jul;
6(Pt 4):714-728.
PMID: 31316815
Efficient and reliable sample delivery has remained one of the bottlenecks for serial crystallography experiments. Compared with other methods, fixed-target sample delivery offers the advantage of significantly reduced sample consumption...
6.
Co-crystal structure of the Fusobacterium ulcerans ZTP riboswitch using an X-ray free-electron laser
Jones C, Tran B, Conrad C, Stagno J, Trachman 3rd R, Fischer P, et al.
Acta Crystallogr F Struct Biol Commun
. 2019 Jul;
75(Pt 7):496-500.
PMID: 31282869
Riboswitches are conformationally dynamic RNAs that regulate gene expression by binding specific small molecules. ZTP riboswitches bind the purine-biosynthetic intermediate 5-aminoimidazole-4-carboxamide riboside 5'-monophosphate (ZMP) and its triphosphorylated form (ZTP). Ligand...
7.
Beyerlein K, Dierksmeyer D, Mariani V, Kuhn M, Sarrou I, Ottaviano A, et al.
IUCrJ
. 2017 Nov;
4(Pt 6):769-777.
PMID: 29123679
Unravelling the interaction of biological macromolecules with ligands and substrates at high spatial and temporal resolution remains a major challenge in structural biology. The development of serial crystallography methods at...
8.
Roedig P, Ginn H, Pakendorf T, Sutton G, Harlos K, Walter T, et al.
Nat Methods
. 2017 Jun;
14(8):805-810.
PMID: 28628129
We report a method for serial X-ray crystallography at X-ray free-electron lasers (XFELs), which allows for full use of the current 120-Hz repetition rate of the Linear Coherent Light Source...
9.
Stellato F, Oberthur D, Liang M, Bean R, Gati C, Yefanov O, et al.
IUCrJ
. 2014 Jul;
1(Pt 4):204-12.
PMID: 25075341
A new approach for collecting data from many hundreds of thousands of microcrystals using X-ray pulses from a free-electron laser has recently been developed. Referred to as serial crystallography, diffraction...