Poh Yong Ng
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Explore the profile of Poh Yong Ng including associated specialties, affiliations and a list of published articles.
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10
Citations
457
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Recent Articles
1.
Chen J, Yang H, Teo A, Amer L, Sherbaf F, Tan C, et al.
Nat Genet
. 2020 Feb;
52(2):177-186.
PMID: 32015526
Lung cancer is the world's leading cause of cancer death and shows strong ancestry disparities. By sequencing and assembling a large genomic and transcriptomic dataset of lung adenocarcinoma (LUAD) in...
2.
Bergin S, Periaswamy B, Barkham T, Chua H, Mok Y, Fung D, et al.
Infect Control Hosp Epidemiol
. 2018 May;
39(7):852-860.
PMID: 29739475
OBJECTIVEWe report the utility of whole-genome sequencing (WGS) conducted in a clinically relevant time frame (ie, sufficient for guiding management decision), in managing a Streptococcus pyogenes outbreak, and present a...
3.
Zhai W, Kiat-Hon Lim T, Zhang T, Phang S, Tiang Z, Guan P, et al.
Nat Commun
. 2017 Feb;
8:4565.
PMID: 28240289
Hepatocellular carcinoma (HCC) has one of the poorest survival rates among cancers. Using multi-regional sampling of nine resected HCC with different aetiologies, here we construct phylogenetic relationships of these sectors,...
4.
Das R, Lee Y, Strogantsev R, Jin S, Lim Y, Ng P, et al.
BMC Genomics
. 2013 Oct;
14:685.
PMID: 24094292
Background: Genomic imprinting is an epigenetically regulated process wherein genes are expressed in a parent-of-origin specific manner. Many imprinted genes were initially identified in mice; some of these were subsequently...
5.
Pan H, Chen L, Dogra S, Teh A, Tan J, Lim Y, et al.
Epigenetics
. 2012 Sep;
7(10):1173-87.
PMID: 22964528
The Infinium Human Methylation450 BeadChip Array (TM) (Infinium 450K) is an important tool for studying epigenetic patterns associated with disease. This array offers a high-throughput, low cost alternative to more...
6.
Zhang J, Hung A, Ng P, Nakayama K, Hu Y, Li B, et al.
Biochem Biophys Res Commun
. 2009 Jul;
386(4):750-6.
PMID: 19563780
A chemical inhibitor library of 84 compounds was screened to investigate the signaling pathway(s) leading to activation of Nrf2 in response to nitric oxide (NO). We identified the protein kinase...
7.
Dhakshinamoorthy S, Sridharan S, Li L, Ng P, Boxer L, Porter A
Nucleic Acids Res
. 2007 Aug;
35(16):5439-51.
PMID: 17702766
Toxic nitric oxide (NO) levels can regulate gene expression. Using a novel protein/DNA array, we show that toxic NO levels regulate the binding of trans-factors to various cis-elements in neuroblastoma...
8.
Urbano A, Lakshmanan U, Choo P, Kwan J, Ng P, Guo K, et al.
EMBO J
. 2005 Jul;
24(15):2815-26.
PMID: 16001080
Apoptosis-inducing factor (AIF) exhibits reactive oxygen species (ROS)-generating NADH oxidase activity of unknown significance, which is dispensable for apoptosis. We knocked out the aif gene in two human colon carcinoma...
9.
Hentze H, Latta M, Kunstle G, Dhakshinamoorthy S, Ng P, Porter A, et al.
Hepatology
. 2004 May;
39(5):1311-20.
PMID: 15122760
Topoisomerases are nuclear enzymes that maintain and modulate DNA structure. Inhibitors of topoisomerases like camptothecin (CPT), etoposide, and others are widely used antitumor drugs that interfere with transcription, induce DNA...
10.
Feng Z, Li L, Ng P, Porter A
Mol Cell Biol
. 2002 Jul;
22(15):5357-66.
PMID: 12101231
c-Jun, a crucial component of the dimeric transcription factor activating protein 1 (AP-1), can regulate apoptosis induced by oxidative stress and has been implicated in neuronal differentiation, but the mechanisms...