Piotr Maciejak
Overview
Explore the profile of Piotr Maciejak including associated specialties, affiliations and a list of published articles.
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Articles
69
Citations
580
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0
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Recent Articles
1.
Wislowska-Stanek A, Turzynska D, Sobolewska A, Kolosowska K, Szyndler J, Skorzewska A, et al.
Pharmacol Rep
. 2024 Mar;
76(2):348-367.
PMID: 38519733
Background: The study aimed to assess the influence of a single valproate (VPA) administration on inhibitory and excitatory neurotransmitter concentrations in the brain structures involved in epileptogenesis in pentylenetetrazol (PTZ)-kindled...
2.
Taracha E, Czarna M, Turzynska D, Sobolewska A, Maciejak P
Psychopharmacology (Berl)
. 2024 Mar;
241(7):1387-1398.
PMID: 38480557
Rationale: Chronic amphetamine (AMPH) use leading to addiction results in adaptive changes within the central nervous system that persist well beyond the drug's elimination from the body and can precipitate...
3.
Taracha E, Czarna M, Turzynska D, Maciejak P
Pharmacol Rep
. 2023 Mar;
75(3):596-608.
PMID: 36944909
Background: A hallmark of psychostimulants is the persistence of neurobiological changes they produce. The difficulty in reversing long-time effects of psychostimulants use is why addiction therapy is so ineffective. This...
4.
Chmielewska N, Wawer A, Wicik Z, Osuch B, Maciejak P, Szyndler J
Neuropharmacology
. 2023 Jan;
227:109425.
PMID: 36709037
The major obstacle in developing new treatment strategies for refractory epilepsy is the complexity and poor understanding of its mechanisms. Utilizing the model of lamotrigine-resistant seizures, we evaluated whether changes...
5.
Kolosowska K, Lehner M, Skorzewska A, Gawryluk A, Tomczuk F, Sobolewska A, et al.
Pharmacol Rep
. 2022 Dec;
75(1):85-98.
PMID: 36586075
Background: Long-term cocaine exposure leads to dysregulation of the reward system and initiates processes that ultimately weaken its rewarding effects. Here, we studied the influence of an escalating-dose cocaine regimen...
6.
Chmielewska N, Wawer A, Osuch B, Maciejak P, Szyndler J
Epilepsy Res
. 2022 Aug;
185:106991.
PMID: 35926274
Although neurotrophic pathways and epigenetic processes are believed to be significant contributors to epileptogenesis and epilepsy, therapies using modulators of these targets are still lacking. BDNF-TrkB-mTOR signalling and the REST/NRSF-coREST-HDAC2...
7.
Osuch B, Kolosowska K, Chmielewska N, Turzynska D, Sobolewska A, Szyndler J, et al.
Neurochem Res
. 2022 May;
47(7):2109-2122.
PMID: 35522366
The efficacy of a ketogenic diet (KD) in controlling seizure has been shown in many experimental and clinical studies, however, its mechanism of action still needs further clarification. The major...
8.
Wislowska-Stanek A, Kolosowska K, Maciejak P
Cells
. 2021 Oct;
10(10).
PMID: 34685499
According to the World Health Organization (WHO), more than 700,000 people die per year due to suicide. Suicide risk factors include a previous suicide attempt and psychiatric disorders. The highest...
9.
Chmielewska N, Maciejak P, Osuch B, Kursa M, Szyndler J
Pharmacol Rep
. 2020 Dec;
73(2):506-515.
PMID: 33377994
Background: The aim of the study was to evaluate the brain-derived proteins, extracellular matrix-derived protein and cytokines as potential peripheral biomarkers of different susceptibility to seizure development in an animal...
10.
Pogoda A, Chmielewska N, Maciejak P, Szyndler J
Curr Med Chem
. 2020 Jul;
28(14):2783-2806.
PMID: 32628586
Huntington's disease (HD) is an inherited neurodegenerative disorder caused by a mutation in the gene that encodes a critical cell regulatory protein, huntingtin (Htt). The expansion of cytosine-adenine-guanine (CAG) trinucleotide...