» Authors » Pilar Alvarez Jerez

Pilar Alvarez Jerez

Explore the profile of Pilar Alvarez Jerez including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 22
Citations 133
Followers 0
Related Specialties
Top 10 Co-Authors
Published In
Affiliations
Soon will be listed here.
Recent Articles
1.
Genner R, Akeson S, Meredith M, Jerez P, Malik L, Baker B, et al.
Genome Res . 2025 Mar; PMID: 40054862
DNA methylation most commonly occurs as 5-methylcytosine (5mC) in the human genome and has been associated with human diseases. Recent developments in single-molecule sequencing technologies (Oxford Nanopore Technologies (ONT) and...
2.
Akcimen F, Paquette K, Wild Crea P, Saffie-Awad P, Achoru C, Taiwo F, et al.
medRxiv . 2025 Jan; PMID: 39867380
Elucidating the genetic contributions to Parkinson's disease (PD) etiology across diverse ancestries is a critical priority for the development of targeted therapies in a global context. We conducted the largest...
3.
Jerez P, Wild Crea P, Ramos D, Gustavsson E, Radefeldt M, Makarious M, et al.
medRxiv . 2025 Jan; PMID: 39802803
Recently, a novel African ancestry specific Parkinson's disease (PD) risk signal was identified at the gene encoding glucocerebrosidase (). This variant (rs3115534-G) is carried by ~50% of West African PD...
4.
Billingsley K, Meredith M, Daida K, Jerez P, Negi S, Malik L, et al.
bioRxiv . 2025 Jan; PMID: 39764002
Structural variants (SVs) drive gene expression in the human brain and are causative of many neurological conditions. However, most existing genetic studies have been based on short-read sequencing methods, which...
5.
Jerez P, Wild Crea P, Ramos D, Gustavsson E, Radefeldt M, Damianov A, et al.
Nat Struct Mol Biol . 2024 Dec; 31(12):1955-1963. PMID: 39668204
Recently, an African ancestry-specific Parkinson disease (PD) risk signal was identified at the gene encoding glucocerebrosidase (GBA1). This variant ( rs3115534 -G) is carried by ~50% of West African PD...
6.
Chen Z, Jerez P, Anderson C, Paucar M, Lee J, Nilsson D, et al.
Mov Disord . 2024 Dec; 40(2):363-369. PMID: 39635987
Background: The identification of a heterozygous exonic GGC repeat expansion in ZFHX3 underlying spinocerebellar ataxia type 4 (SCA4) has solved a 25-year diagnostic conundrum. We used adaptive long-read sequencing to...
7.
Dwarshuis N, Kalra D, McDaniel J, Sanio P, Jerez P, Jadhav B, et al.
Nat Commun . 2024 Oct; 15(1):9029. PMID: 39424793
Despite the growing variety of sequencing and variant-calling tools, no workflow performs equally well across the entire human genome. Understanding context-dependent performance is critical for enabling researchers, clinicians, and developers...
8.
Jerez P, Daida K, Grenn F, Malik L, Miano-Burkhardt A, Makarious M, et al.
NPJ Parkinsons Dis . 2024 Jul; 10(1):136. PMID: 39060285
Parkinson's disease (PD) is a common neurodegenerative disorder with a significant risk proportion driven by genetics. While much progress has been made, most of the heritability remains unknown. This is...
9.
Jerez P, Daida K, Miano-Burkhardt A, Iwaki H, Malik L, Cogan G, et al.
NPJ Parkinsons Dis . 2024 May; 10(1):108. PMID: 38789445
A biallelic (AAGGG) expansion in the poly(A) tail of an AluSx3 transposable element within the gene RFC1 is a frequent cause of cerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS), and...
10.
Miano-Burkhardt A, Jerez P, Daida K, Ciga S, Billingsley K
Int J Mol Sci . 2024 May; 25(9). PMID: 38732020
Parkinson's disease (PD) significantly impacts millions of individuals worldwide. Although our understanding of the genetic foundations of PD has advanced, a substantial portion of the genetic variation contributing to disease...