Pietro Pichierri
Overview
Explore the profile of Pietro Pichierri including associated specialties, affiliations and a list of published articles.
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Articles
57
Citations
1392
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Recent Articles
1.
Noto A, Valenzisi P, Di Feo F, Fratini F, Kulikowicz T, Sommers J, et al.
Nat Commun
. 2025 Jan;
16(1):997.
PMID: 39870632
The WRN protein is vital for managing perturbed replication forks. Replication Protein A strongly enhances WRN helicase activity in specific in vitro assays. However, the in vivo significance of RPA...
2.
Palermo V, Malacaria E, Semproni M, Camerini S, Casella M, Perdichizzi B, et al.
Nucleic Acids Res
. 2024 Sep;
52(20):12334-12350.
PMID: 39315694
Replication-dependent DNA double-strand breaks are harmful lesions preferentially repaired by homologous recombination (HR), a process that requires processing of DNA ends to allow RAD51-mediated strand invasion. End resection and subsequent...
3.
Perdichizzi B, Pichierri P
MicroPubl Biol
. 2024 May;
2024.
PMID: 38764946
Double-strand breaks (DSBs) can cause chromosome rearrangements, leading to cancer and some genetic diseases. WRN and SAMHD1 are proteins implicated in DSB processing and form a complex. Our study shows...
4.
Valenzisi P, Marabitti V, Pichierri P, Franchitto A
Elife
. 2024 Mar;
12.
PMID: 38488661
R-loops are non-canonical DNA structures that form during transcription and play diverse roles in various physiological processes. Disruption of R-loop homeostasis can lead to genomic instability and replication impairment, contributing...
5.
Honda M, Razzaghi M, Gaur P, Malacaria E, Marozzi G, Biagi L, et al.
bioRxiv
. 2023 Nov;
PMID: 38014173
One Sentence Summary: Using cryo-EM, biochemical and single-molecule approaches we show that the structure of stalled DNA replication fork promotes a unique two-ring organization of human RAD52 protein which remodels...
6.
Noto A, Valenzisi P, Fratini F, Kulikowicz T, Sommers J, Di Feo F, et al.
bioRxiv
. 2023 Aug;
PMID: 37609214
The WRN protein mutated in the hereditary premature aging disorder Werner syndrome plays a vital role in handling, processing, and restoring perturbed replication forks. One of its most abundant partners,...
7.
Blandino F, Malacaria E, Figlioli C, Noto A, Pugliese G, Franchitto A, et al.
Nucleic Acids Res
. 2023 May;
51(13):6723-6737.
PMID: 37254810
The MUS81 complex is crucial for preserving genome stability through resolution of branched DNA intermediates in mitosis and also for the processing of deprotected replication forks in BRCA2-deficient cells. Because...
8.
Bhat D, Malacaria E, Biagi L, Razzaghi M, Honda M, Hobbs K, et al.
NAR Cancer
. 2023 May;
5(2):zcad018.
PMID: 37139244
RAD52 protein is a coveted target for anticancer drug discovery. Similar to poly-ADP-ribose polymerase (PARP) inhibitors, pharmacological inhibition of RAD52 is synthetically lethal with defects in genome caretakers BRCA1 and...
9.
Biagi L, Marozzi G, Malacaria E, Honda M, Aiello F, Valenzisi P, et al.
bioRxiv
. 2023 Apr;
PMID: 37090680
Replication gaps can arise as a consequence of perturbed DNA replication and their accumulation might undermine the stability of the genome. Loss of RAD52, a protein involved in the regulation...
10.
Priolo M, Palermo V, Aiello F, Ciolfi A, Pannone L, Muto V, et al.
Clin Genet
. 2022 Apr;
102(1):12-21.
PMID: 35396703
Prompt diagnosis of complex phenotypes is a challenging task in clinical genetics. Whole exome sequencing has proved to be effective in solving such conditions. Here, we report on an unpredictable...