Pieter Okkerse
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Explore the profile of Pieter Okkerse including associated specialties, affiliations and a list of published articles.
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Articles
10
Citations
102
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0
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Recent Articles
1.
Okkerse P, Berendsen R, Schoe A
Minerva Anestesiol
. 2021 Jul;
87(10):1152-1154.
PMID: 34263584
No abstract available.
2.
van Amerongen G, Siebenga P, Gurrell R, Dua P, Whitlock M, Gorman D, et al.
Br J Anaesth
. 2019 Mar;
123(2):e194-e203.
PMID: 30915991
Background: This study investigated the analgesic effects of two doses (15 and 65 mg) of PF-06372865, a novel α2/α3/α5 gamma-aminobutyric acid A (GABA) subunit selective partial positive allosteric modulator (PAM),...
3.
Siebenga P, van Amerongen G, Okkerse P, Denney W, Dua P, Butt R, et al.
Eur J Pain
. 2019 Feb;
23(6):1129-1140.
PMID: 30793411
Background: Although reproducibility is considered essential for any method used in scientific research, it is investigated only rarely; thus, strikingly little has been published regarding the reproducibility of evoked pain...
4.
van Esdonk M, Lindeman I, Okkerse P, de Kam M, Groeneveld G, Stevens J
CPT Pharmacometrics Syst Pharmacol
. 2018 Jul;
7(9):573-580.
PMID: 30043517
A battery of pain models can be used in clinical trials to investigate the efficacy and to establish the concentration-effect relationship of novel analgesics. This study quantified the pharmacokinetics (PK)...
5.
Okkerse P, Hay J, Sitsen E, Dahan A, Klaassen E, Houghton W, et al.
Br J Clin Pharmacol
. 2016 Dec;
83(4):751-763.
PMID: 27987228
Aim: Xen2174 is a synthetic 13-amino acid peptide that binds specifically to the norepinephrine transporter, which results in inhibition of norepinephrine uptake. It is being developed as a possible treatment...
6.
Okkerse P, van Amerongen G, de Kam M, Stevens J, Butt R, Gurrell R, et al.
Br J Clin Pharmacol
. 2016 Nov;
83(5):976-990.
PMID: 27862179
Aim: The aim was to investigate the ability of a battery of pain models to detect analgesic properties of commonly used analgesics in healthy subjects. Methods: The battery consisted of...
7.
Wilhelmus M, Hay J, Zuiker R, Okkerse P, Perdrieu C, Sauser J, et al.
J Psychopharmacol
. 2016 Sep;
31(2):222-232.
PMID: 27649778
Caffeine induces positive effects on sustained attention, although studies assessing the acute effects of low caffeine dose (<75 mg) on sustained attention are limited and use short-term tests. Therefore, we...
8.
Hay J, Okkerse P, van Amerongen G, Groeneveld G
J Vis Exp
. 2016 May;
(110).
PMID: 27166581
Human pain models are useful in the assessing the analgesic effect of drugs, providing information about a drug's pharmacology and identify potentially suitable therapeutic populations. The need to use a...
9.
Okkerse P, Hay J, Versage E, Tang Y, Galluppi G, Ravina B, et al.
Br J Clin Pharmacol
. 2016 Mar;
82(1):108-17.
PMID: 27016000
Aims: BG00010 is a protein in the glial cell line-derived neurotrophic factor (GDNF) family. It is a selective ligand for the GDNF family receptor alpha-3 (GFRα3) co-receptor that normalizes cellular...
10.
Roozekrans M, van der Schrier R, Okkerse P, Hay J, McLeod J, Dahan A
Anesthesiology
. 2014 Sep;
121(3):459-68.
PMID: 25222672
Background: Opioid-induced respiratory depression is potentially lethal. GAL021 is a calcium-activated potassium (BKCa) channel blocker that causes reversal of opioid-induced respiratory depression in animals due to a stimulatory effect on...