Pieter H Reitsma
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Explore the profile of Pieter H Reitsma including associated specialties, affiliations and a list of published articles.
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122
Citations
2557
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Recent Articles
11.
Schreuder M, Reitsma P, Bos M
J Thromb Haemost
. 2019 May;
17(8):1229-1239.
PMID: 31102425
Blood coagulation factor Va serves an indispensable role in hemostasis as cofactor for the serine protease factor Xa. In the presence of an anionic phospholipid membrane and calcium ions, factors...
12.
Heestermans M, de Jong A, van Tilburg S, Reitsma P, Versteeg H, Spronk H, et al.
Nucleic Acid Ther
. 2019 May;
29(4):218-223.
PMID: 31063435
Recently, our group reported that a small interfering RNA (siRNA) targeting coagulation factor XII (si) leads to an unexpected prothrombotic response in a mouse model where venous thrombosis follows inhibition...
13.
Heestermans M, Salloum-Asfar S, Streef T, Laghmani E, Salvatori D, Luken B, et al.
Blood
. 2019 Mar;
133(19):2090-2099.
PMID: 30898865
Tissue factor, coagulation factor XII, platelets, and neutrophils are implicated as important players in the pathophysiology of (experimental) venous thrombosis (VT). Their role became evident in mouse models in which...
14.
Rietveld I, Schreuder M, Reitsma P, Bos M
Thromb Res
. 2018 Nov;
172:104-109.
PMID: 30408635
Introduction: Altered levels of factor (F)VIII, prothrombin, or antithrombin have been associated with an increased risk for venous thromboembolism (VTE). However, the exact molecular mechanism by which these altered factor...
15.
Heestermans M, Ouweneel A, Hassan J, Kloosterman M, Reitsma P, Gijbels M, et al.
Sci Rep
. 2018 Oct;
8(1):15106.
PMID: 30305662
Silencing of anticoagulant protein C using RNA interference (siProc) evokes low incident but spontaneous atherothrombosis in the aortic root of apolipoprotein E-deficient (Apoe) mice. The aims of the current study...
16.
Rietveld I, Bos M, Lijfering W, Li-Gao R, Rosendaal F, Reitsma P, et al.
Res Pract Thromb Haemost
. 2018 Jul;
2(2):320-326.
PMID: 30046734
Background: Blood coagulation levels are associated with risk of venous thrombosis (VT). The role of factor (F)V is ambiguous since it plays a dual role in coagulation: it has a...
17.
Huisman M, Barco S, Cannegieter S, Le Gal G, Konstantinides S, Reitsma P, et al.
Nat Rev Dis Primers
. 2018 May;
4:18028.
PMID: 29770793
Pulmonary embolism (PE) is caused by emboli, which have originated from venous thrombi, travelling to and occluding the arteries of the lung. PE is the most dangerous form of venous...
18.
Cunha M, Meijers J, Rosendaal F, van Hylckama Vlieg A, Reitsma P, Middeldorp S
PLoS One
. 2017 Nov;
12(11):e0187699.
PMID: 29117201
Background: Family studies have shown a strong heritability component for venous thromboembolism (VTE), but established genetic risk factors are present in only half of VTE patients. Aim: To identify genetic...
19.
van Rein N, de Geus K, Cannegieter S, Reitsma P, van der Meer F, Lijfering W
Pharmacoepidemiol Drug Saf
. 2017 Nov;
27(1):46-51.
PMID: 29108127
Purpose: Multi-dose drug dispensing (MDD) is a dosing aid that provides patients with disposable bags containing all drugs intended for 1 dosing moment. MDD is believed to increase medication adherence,...
20.
Verhoef D, Visscher K, Vosmeer C, Cheung K, Reitsma P, Geerke D, et al.
Nat Commun
. 2017 Sep;
8(1):528.
PMID: 28904343
The absence of an adequate reversal strategy to prevent and stop potential life-threatening bleeding complications is a major drawback to the clinical use of the direct oral inhibitors of blood...