Pieter De Bruyn
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Explore the profile of Pieter De Bruyn including associated specialties, affiliations and a list of published articles.
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9
Citations
237
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Recent Articles
1.
Vandierendonck J, Girardin Y, De Bruyn P, De Greve H, Loris R
Toxins (Basel)
. 2023 Aug;
15(8).
PMID: 37624265
Molecular cloning and controlled expression remain challenging when the target gene encodes a protein that is toxic to the host. We developed a set of multi-layer control systems to enable...
2.
Jurenas D, Fraikin N, Goormaghtigh F, De Bruyn P, Vandervelde A, Zedek S, et al.
mBio
. 2021 Nov;
12(6):e0294721.
PMID: 34844426
Type II toxin-antitoxin (TA) systems are classically composed of two genes that encode a toxic protein and a cognate antitoxin protein. Both genes are organized in an operon whose expression...
3.
De Bruyn P, Prolic-Kalinsek M, Vandervelde A, Malfait M, Sterckx Y, Sobott F, et al.
Acta Crystallogr F Struct Biol Commun
. 2021 Oct;
77(Pt 10):374-384.
PMID: 34605442
paaR2-paaA2-parE2 is a three-component toxin-antitoxin module found in prophage CP-993P of Escherichia coli O157:H7. Transcription regulation of this module occurs via the 123-amino-acid regulator PaaR2, which forms a large oligomeric...
4.
De Bruyn P, Girardin Y, Loris R
Protein Sci
. 2021 Mar;
30(6):1103-1113.
PMID: 33786944
Toxin-antitoxin (TA) modules are small operons in bacteria and archaea that encode a metabolic inhibitor (toxin) and a matching regulatory protein (antitoxin). While their biochemical activities are often well defined,...
5.
Yperman K, Wang J, Eeckhout D, Winkler J, Vu L, Vandorpe M, et al.
Sci Adv
. 2021 Feb;
7(9).
PMID: 33637534
Eukaryotic cells rely on endocytosis to regulate their plasma membrane proteome and lipidome. Most eukaryotic groups, except fungi and animals, have retained the evolutionary ancient TSET complex as an endocytic...
6.
Prolic-Kalinsek M, De Bruyn P, Jurenas D, Van Melderen L, Loris R, Volkov A
Biomol NMR Assign
. 2019 Oct;
14(1):25-30.
PMID: 31625047
The cryptic prophage CP-933P in Escherichia coli O157:H7 contains a parDE-like toxin-antitoxin module, the operator region of which is recognized by two flanking transcription regulators: PaaR2 (ParE associated Regulator), which...
7.
De Bruyn P, Hadzi S, Vandervelde A, Konijnenberg A, Prolic-Kalinsek M, Sterckx Y, et al.
Biophys J
. 2019 Apr;
116(8):1420-1431.
PMID: 30979547
PaaR2 is a putative transcription regulator encoded by a three-component parDE-like toxin-antitoxin module from Escherichia coli O157:H7. Although this module's toxin, antitoxin, and toxin-antitoxin complex have been more thoroughly investigated,...
8.
Conceicao-Neto N, Zeller M, Lefrere H, De Bruyn P, Beller L, Deboutte W, et al.
Sci Rep
. 2015 Nov;
5:16532.
PMID: 26559140
A major limitation for better understanding the role of the human gut virome in health and disease is the lack of validated methods that allow high throughput virome analysis. To...
9.
De Bruyn P, Cardinaels R, Moldenaers P
J Colloid Interface Sci
. 2013 Aug;
409:183-92.
PMID: 23988082
Droplet coalescence is determined by the combined effect of the collision frequency and the coalescence efficiency of colliding droplets. In the present work, the effect of geometrical confinement on coalescence...