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Pieter A van der Velden

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Recent Articles
11.
Souri Z, Wierenga A, Kroes W, van der Velden P, Verdijk R, Eikmans M, et al.
Cancers (Basel) . 2021 Sep; 13(17). PMID: 34503258
Uveal melanoma (UM) is a rare ocular malignancy which originates in the uveal tract, and often gives rise to metastases. Potential targets for immune checkpoint inhibition are lymphocyte-activation gene 3...
12.
Souri Z, Jochemsen A, Wierenga A, Kroes W, Verdijk R, van der Velden P, et al.
Cancers (Basel) . 2021 Aug; 13(16). PMID: 34439300
In Uveal Melanoma (UM), an inflammatory phenotype is strongly associated with the development of metastases and with chromosome 3/BAP1 expression loss. As an increased expression of several Histone Deacetylases (HDACs)...
13.
Souri Z, Wierenga A, Kilic E, Brosens E, Bohringer S, Kroes W, et al.
Cancers (Basel) . 2021 Aug; 13(16). PMID: 34439175
MicroRNAs are known to play a role in the regulation of inflammation. As a high HLA Class I expression is associated with a bad prognosis in UM, we set out...
14.
Ten Voorde A, Wierenga A, Nell R, van der Velden P, Luyten G, Verdijk R, et al.
Cancers (Basel) . 2021 Aug; 13(16). PMID: 34439141
Uveal melanoma (UM) metastasize haematogeneously, and tumor blood vessel density is an important prognostic factor. We hypothesized that proangiogenic factors such as angiopoietin-1 (ANG-1) and angiopoietin-2 (ANG-2), two targetable cytokines,...
15.
Nell R, Menger N, Versluis M, Luyten G, Verdijk R, Madigan M, et al.
BMC Cancer . 2021 Feb; 21(1):164. PMID: 33588787
Background: Activating Gα signalling mutations are considered an early event in the development of uveal melanoma. Whereas most tumours harbour a mutation in GNAQ or GNA11, CYSLTR2 (encoding G-protein coupled...
16.
Souri Z, Jochemsen A, Versluis M, Wierenga A, Nemati F, van der Velden P, et al.
Cancers (Basel) . 2020 Dec; 12(12). PMID: 33316946
The treatment of uveal melanoma (UM) metastases or adjuvant treatment may imply immunological approaches or chemotherapy. It is to date unknown how epigenetic modifiers affect the expression of immunologically relevant...
17.
Nell R, van Steenderen D, Menger N, Weitering T, Versluis M, van der Velden P
Hum Mutat . 2020 Sep; 41(12):2205-2216. PMID: 32906203
Epigenetic regulation is important in human health and disease, but the exact mechanisms remain largely enigmatic. DNA methylation represents one epigenetic aspect but is challenging to quantify. In this study,...
18.
Christodoulou E, Nell R, Verdijk R, Gruis N, van der Velden P, van Doorn R
J Invest Dermatol . 2020 Apr; 140(11):2298-2301.e3. PMID: 32234459
No abstract available.
19.
Dogrusoz M, Brouwer N, de Geus S, Ly L, Bohringer S, van Duinen S, et al.
Invest Ophthalmol Vis Sci . 2020 Mar; 61(3):31. PMID: 32186672
Purpose: A subgroup of uveal melanoma (UM) gives rise to metastases at a late stage. Our objective was to identify patient and tumor characteristics that are associated with UM-related death...
20.
Piaggio F, Tozzo V, Bernardi C, Croce M, Puzone R, Viaggi S, et al.
Cancers (Basel) . 2019 Nov; 11(11). PMID: 31671564
Background: Uveal melanoma (UM), a rare cancer of the eye, is characterized by initiating mutations in the genes G-protein subunit alpha Q (), G-protein subunit alpha 11 (), cysteinyl leukotriene...