Pierre Vanderhaeghen
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Explore the profile of Pierre Vanderhaeghen including associated specialties, affiliations and a list of published articles.
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76
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3762
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Recent Articles
1.
Pasca S, Arlotta P, Bateup H, Camp J, Cappello S, Gage F, et al.
Nature
. 2024 Dec;
639(8054):315-320.
PMID: 39653126
As the field of neural organoids and assembloids expands, there is an emergent need for guidance and advice on designing, conducting and reporting experiments to increase the reproducibility and utility...
2.
Libe-Philippot B, Iwata R, Recupero A, Wierda K, Bernal Garcia S, Hammond L, et al.
Neuron
. 2024 Oct;
112(21):3602-3617.e9.
PMID: 39406239
Human-specific (HS) genes have been implicated in brain evolution, but their impact on human neuron development and diseases remains unclear. Here, we study SRGAP2B/C, two HS gene duplications of the...
3.
Libe-Philippot B, Polleux F, Vanderhaeghen P
Curr Opin Genet Dev
. 2024 Oct;
89:102260.
PMID: 39357501
Animal speciation often involves novel behavioral features that rely on nervous system evolution. Human-specific brain features have been proposed to underlie specialized cognitive functions and to be linked, at least...
4.
Assendorp N, Fossati M, Libe-Philippot B, Christopoulou E, Depp M, Rapone R, et al.
Cell Rep
. 2024 Oct;
43(10):114797.
PMID: 39352808
Human-specific genes are potential drivers of brain evolution. Among them, SRGAP2C has contributed to the emergence of features characterizing human cortical synapses, including their extended period of maturation. SRGAP2C inhibits...
5.
Wierda K, Nyitrai H, Lejeune A, Vlaeminck I, Leysen E, Theys T, et al.
STAR Protoc
. 2024 Sep;
5(4):103313.
PMID: 39292560
Cerebral cortex biopsies enable the investigation of native developing and mature human brain tissue. Here, we present a protocol to process human cortical biopsies from the surgical theater to the...
6.
Vermaercke B, Iwata R, Wierda K, Boubakar L, Rodriguez P, Ditkowska M, et al.
Neuron
. 2024 Aug;
112(18):3058-3068.e8.
PMID: 39111306
Human brain ontogeny is characterized by a considerably prolonged neotenic development of cortical neurons and circuits. Neoteny is thought to be essential for the acquisition of advanced cognitive functions, which...
7.
Iwata R, Vanderhaeghen P
Dev Cell
. 2024 Jun;
59(13):1628-1639.
PMID: 38906137
Development consists of a highly ordered suite of steps and transitions, like choreography. Although these sequences are often evolutionarily conserved, they can display species variations in duration and speed, thereby...
8.
Casimir P, Iwata R, Vanderhaeghen P
Curr Opin Genet Dev
. 2024 Mar;
86:102182.
PMID: 38555796
Changes in developmental timing are an important factor of evolution in organ shape and function. This is particularly striking for human brain development, which, compared with other mammals, is considerably...
9.
Libe-Philippot B, Lejeune A, Wierda K, Louros N, Erkol E, Vlaeminck I, et al.
Cell
. 2023 Dec;
186(26):5766-5783.e25.
PMID: 38134874
The enhanced cognitive abilities characterizing the human species result from specialized features of neurons and circuits. Here, we report that the hominid-specific gene LRRC37B encodes a receptor expressed in human...
10.
Atsumi Y, Iwata R, Kimura H, Vanderhaeghen P, Yamamoto N, Sugo N
Cell Rep
. 2023 Dec;
43(1):113576.
PMID: 38128530
Neuronal activity-dependent transcription plays a key role in plasticity and pathology in the brain. An intriguing question is how neuronal activity controls gene expression via interactions of transcription factors with...