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Pia Siljander

Explore the profile of Pia Siljander including associated specialties, affiliations and a list of published articles. Areas
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Articles 20
Citations 1978
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Recent Articles
1.
Boilard E, Burger D, Buzas E, Gresele P, Machlus K, Mackman N, et al.
Circ Res . 2025 Feb; 136(4):442-452. PMID: 39946441
Platelets are abundant in blood, where they maintain the integrity of the vasculature. Megakaryocytes, the cells responsible for platelet genesis, produce membrane protrusions from which as many as 5000 anucleate...
2.
Helin T, Palviainen M, Lemponen M, Maaninka K, Siljander P, Joutsi-Korhonen L
Platelets . 2024 Feb; 35(1):2313362. PMID: 38380806
Coagulation disturbances are major contributors to COVID-19 pathogenicity, but limited data exist on the involvement of extracellular vesicles (EVs) and residual cells (RCs). Fifty hospitalized COVID-19 patients stratified by their...
3.
Barreiro K, Dwivedi O, Valkonen S, Groop P, Tuomi T, Holthofer H, et al.
J Extracell Vesicles . 2021 Oct; 10(12):e12158. PMID: 34651466
Urinary extracellular vesicles (uEV) are a topical source of non-invasive biomarkers for health and diseases of the urogenital system. However, several challenges have become evident in the standardization of uEV...
4.
Palviainen M, Laukkanen K, Tavukcuoglu Z, Velagapudi V, Karkkainen O, Hanhineva K, et al.
Cancers (Basel) . 2020 Nov; 12(11). PMID: 33172086
Cancer alters cell metabolism. How these changes are manifested in the metabolite cargo of cancer-derived extracellular vesicles (EVs) remains poorly understood. To explore these changes, EVs from prostate, cutaneous T-cell...
5.
Koponen A, Kerkela E, Rojalin T, Lazaro-Ibanez E, Suutari T, Saari H, et al.
Biosens Bioelectron . 2020 Sep; 168:112510. PMID: 32877783
Extracellular vesicles (EVs) have the ability to function as molecular vehicles and could therefore be harnessed to deliver drugs to target cells in diseases such as cancer. The composition of...
6.
Gasecka A, Nieuwland R, Budnik M, Dignat-George F, Eyileten C, Harrison P, et al.
J Thromb Haemost . 2019 Dec; 18(3):609-623. PMID: 31833175
Background: Platelet P2Y12 antagonist ticagrelor reduces mortality after acute myocardial infarction (AMI) compared to clopidogrel, but the underlying mechanism is unknown. Because activated platelets, leukocytes, and endothelial cells release proinflammatory...
7.
Multia E, Tear C, Palviainen M, Siljander P, Riekkola M
Anal Chim Acta . 2019 Nov; 1091:160-168. PMID: 31679569
A new, fast and selective immunoaffinity chromatographic method including a methacrylate-based convective interaction media (CIM®) disk monolithic column, immobilized with anti-human CD61 antibody, was developed for the isolation of CD61-containing...
8.
Gasecka A, Nieuwland R, Budnik M, Dignat-George F, Eyileten C, Harrison P, et al.
Platelets . 2018 Dec; 31(1):26-32. PMID: 30585111
Activated platelets contribute to thrombosis and inflammation by the release of extracellular vesicles (EVs) exposing P-selectin, phosphatidylserine (PS) and fibrinogen. P2Y12 receptor antagonists are routinely administered to inhibit platelet activation...
9.
Endzelins E, Abols A, Buss A, Zandberga E, Palviainen M, Siljander P, et al.
Anticancer Res . 2018 Sep; 38(9):5139-5147. PMID: 30194161
Background/aim: Tumor-secreted extracellular vesicles (EVs) play an important role as mediators of intercellular communication. Hypoxia is a common feature of solid tumors frequently associated with an aggressive clinical behavior. This...
10.
Kornilov R, Puhka M, Mannerstrom B, Hiidenmaa H, Peltoniemi H, Siljander P, et al.
J Extracell Vesicles . 2018 Feb; 7(1):1422674. PMID: 29410778
Fetal bovine serum (FBS) is the most commonly used supplement in studies involving cell-culture experiments. However, FBS contains large numbers of bovine extracellular vesicles (EVs), which hamper the analyses of...