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Philippe A Melas

Explore the profile of Philippe A Melas including associated specialties, affiliations and a list of published articles. Areas
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Articles 35
Citations 623
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Recent Articles
1.
Hong M, Khemiri L, Guterstam J, Franck J, Jayaram-Lindstrom N, Melas P
Pharmacol Rep . 2025 Mar; PMID: 40069537
Background: OSU6162, a monoamine stabilizer, has demonstrated efficacy in reducing alcohol and anxiety-related behaviors in preclinical settings. In a previous randomized, double-blind, placebo-controlled trial involving patients with alcohol dependence (AD),...
2.
Verhoeven J, Wolkowitz O, Barr Satz I, Conklin Q, Lamers F, Lavebratt C, et al.
Bioessays . 2024 Sep; 46(10):e2300246. PMID: 39258367
Clinical mental health researchers may understandably struggle with how to incorporate biological assessments in clinical research. The options are numerous and are described in a vast and complex body of...
3.
Cai W, Forsell Y, Lavebratt C, Melas P
Sci Rep . 2024 Jul; 14(1):17566. PMID: 39080362
Associations between the fat mass and obesity-associated (FTO) gene and obesity are well-established. However, recent studies have linked FTO to addiction phenotypes and dopaminergic signaling, thus suggesting broader psychiatric implications....
4.
Cai W, Pierzynowska K, Stiernborg M, Xu J, Nilsson I, Svensson U, et al.
Clin Nutr ESPEN . 2024 Jun; 63:74-83. PMID: 38923468
Background: Inflammatory bowel disease (IBD) is characterized by recurrent inflammation of the gastrointestinal tract and has been linked to an imbalance in gut bacteria. Synbiotics, which combine probiotics and prebiotics,...
5.
Stiernborg M, Prast-Nielsen S, Melas P, Skott M, Millischer V, Boulund F, et al.
Brain Behav Immun . 2024 Jan; 117:298-309. PMID: 38280535
While an association between the gut microbiome and schizophrenia spectrum disorders (SSD) has been suggested, the existing evidence is still inconclusive. To this end, we analyzed bacteria and bacterial genes...
6.
Bornscheuer L, Lundin A, Forsell Y, Lavebratt C, Melas P
Genes (Basel) . 2023 Sep; 14(9). PMID: 37761966
Fatty acid amide hydrolase (FAAH) is an enzyme that degrades anandamide, an endocannabinoid that modulates mesolimbic dopamine release and, consequently, influences states of well-being. Despite these known interactions, the specific...
7.
Stiernborg M, Debelius J, Yang L, Skott E, Millischer V, Giacobini M, et al.
Brain Behav Immun . 2023 Mar; 110:310-321. PMID: 36940753
Recent evidence suggests that there is a link between neurodevelopmental disorders, such as attention-deficit hyperactivity disorder (ADHD), and the gut microbiome. However, most studies to date have had low sample...
8.
Qvist J, Scherma M, Jayaram-Lindstrom N, Fratta W, Kandel D, Kandel E, et al.
Int J Mol Sci . 2023 Jan; 24(1). PMID: 36614142
The regular use of cannabis during adolescence has been associated with a number of negative life outcomes, including psychopathology and cognitive impairments. However, the exact molecular mechanisms that underlie these...
9.
Fredriksson I, Jayaram-Lindstrom N, Kalivas P, Melas P, Steensland P
Behav Brain Res . 2022 Sep; 436:114089. PMID: 36063970
Increasing evidence suggests that individuals with alcohol use disorder (AUD) present with a disrupted glutamatergic system that underlies core components of addictive disorders, including drug relapse and low impulse control....
10.
Bornscheuer L, Lundin A, Forsell Y, Lavebratt C, Melas P
Sci Rep . 2022 Mar; 12(1):4963. PMID: 35322131
Problematic alcohol use is a major contributor to the global burden of death and disabilities, and it represents a public health concern that has grown substantially following the COVID-19 pandemic....