Philip S Boonstra
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Explore the profile of Philip S Boonstra including associated specialties, affiliations and a list of published articles.
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55
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1053
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Recent Articles
1.
Boonstra P, Orozco Del Pino P
J R Stat Soc Ser A Stat Soc
. 2025 Jan;
188(1):46-67.
PMID: 39810879
Model integration refers to the process of incorporating a fitted historical model into the estimation of a current study to increase statistical efficiency. Integration can be challenging when the current...
2.
Boonstra P, Owen D, Kang J
Pharm Stat
. 2024 Feb;
23(4):540-556.
PMID: 38400582
Motivated by the need to model dose-response or dose-toxicity curves in clinical trials, we develop a new horseshoe-based prior for Bayesian isotonic regression modeling a binary outcome against an ordered...
3.
Tonna J, Boonstra P, MacLaren G, Paden M, Brodie D, Anders M, et al.
ASAIO J
. 2024 Jan;
70(2):131-143.
PMID: 38181413
The Extracorporeal Life Support Organization (ELSO) maintains the world's largest extracorporeal membrane oxygenation (ECMO) registry by volume, center participation, and international scope. This 2022 ELSO Registry Report describes the program...
4.
Strohbehn G, Stadler W, Boonstra P, Ratain M
Clin Trials
. 2023 Dec;
21(3):340-349.
PMID: 38148731
Since the middle of the 20th century, oncology's dose-finding paradigm has been oriented toward identifying a drug's maximum tolerated dose, which is then carried forward into phase 2 and 3...
5.
Chase E, Taylor J, Boonstra P
Stat Med
. 2023 Dec;
43(5):817-832.
PMID: 38095078
Biomedical data often exhibit jumps or abrupt changes. For example, women's basal body temperature may jump at ovulation, menstruation, implantation, and miscarriage. These sudden changes make these data challenging to...
6.
Boonstra P, Tabarrok A, Strohbehn G
PLoS One
. 2023 Oct;
18(10):e0287511.
PMID: 37903093
Administering drug at a dose lower than that used in pivotal clinical trials, known as fractional dosing, can stretch scarce resources. Implementing fractional dosing with confidence requires understanding a drug's...
7.
Delaney P, Eisner Z, Thullah A, Turay P, Sandy K, Boonstra P, et al.
Injury
. 2022 Oct;
54(1):5-14.
PMID: 36266111
Introduction: The global injury burden, driven by road traffic injuries, disproportionately affects low- and middle-income countries, which lack robust emergency medical services (EMS) to address injury. The WHO recommends training...
8.
Kohne J, MacLaren G, Cagino L, Boonstra P, Brodie D, Barbaro R
Crit Care Med
. 2022 May;
50(9):1360-1370.
PMID: 35607973
Objectives: The use of extracorporeal membrane oxygenation (ECMO) in patients with COVID-19 has been supported by major healthcare organizations, yet the role of specific management strategies during ECMO requires further...
9.
Li P, Taylor J, Boonstra P, Lawrence T, Schipper M
Stat Med
. 2022 Mar;
41(16):2957-2977.
PMID: 35343595
The goal in personalized medicine is to individualize treatment using patient characteristics and improve health outcomes. Selection of optimal dose must balance the effect of dose on both treatment efficacy...
10.
West B, Little R, Andridge R, Boonstra P, Ware E, Pandit A, et al.
Ann Appl Stat
. 2022 Mar;
15(3):1556-1581.
PMID: 35237377
Selection bias is a serious potential problem for inference about relationships of scientific interest based on samples without well-defined probability sampling mechanisms. Motivated by the potential for selection bias in:...