Philip Homan
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Explore the profile of Philip Homan including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
163
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Recent Articles
1.
Zhang L, Norberg S, Karimipour F, Davies J, Kuznetsov A, Lassoued W, et al.
J Immunother Cancer
. 2024 Nov;
12(11).
PMID: 39557544
Background: Adoptive T-cell therapy has demonstrated clinical activity in B-cell malignancies, offering hope for its application to a broad spectrum of cancers. However, a significant portion of patients with solid...
2.
Parmar S, Bume D, Connelly C, Boer R, Prestwood P, Wang Z, et al.
Nat Commun
. 2024 Sep;
15(1):8173.
PMID: 39289353
Riboswitches are structured RNA elements that regulate gene expression upon binding to small molecule ligands. Understanding the mechanisms by which small molecules impact riboswitch activity is key to developing potent,...
3.
Parmar S, Bume D, Conelly C, Boer R, Prestwood P, Wang Z, et al.
bioRxiv
. 2024 Jun;
PMID: 38903087
Riboswitches are structured RNA elements that regulate gene expression upon binding to small molecule ligands. Understanding the mechanisms by which small molecules impact riboswitch activity is key to developing potent,...
4.
Rosati M, Terpos E, Homan P, Bergamaschi C, Karaliota S, Ntanasis-Stathopoulos I, et al.
Front Immunol
. 2023 Dec;
14:1292568.
PMID: 38090597
Introduction: Cytokines and chemokines play an important role in shaping innate and adaptive immunity in response to infection and vaccination. Systems serology identified immunological parameters predictive of beneficial response to...
5.
Monge C, Xie C, Myojin Y, Coffman K, Hrones D, Wang S, et al.
J Immunother Cancer
. 2023 Feb;
11(2).
PMID: 36754451
Background: Oncolytic immunotherapy represents a unique therapeutic platform for the treatment of cancer. Here, we evaluated the safety and efficacy of the combination of pexastimogene devacirepvec (PexaVec) plus durvalumab (anti-programmed...
6.
Daenthanasanmak A, Bamford R, Yoshioka M, Yang S, Homan P, Karim B, et al.
Blood Adv
. 2022 Jan;
6(7):2346-2360.
PMID: 35030628
Adult T-cell leukemia/lymphoma (ATL) is an aggressive T-cell lymphoproliferative malignancy caused by human T-cell leukemia virus type 1 (HTLV-1). ATL is an orphan disease with no curative drug treatment regimens...
7.
Lichtenstein D, Schischlik F, Shao L, Steinberg S, Yates B, Wang H, et al.
Blood
. 2021 Sep;
138(24):2469-2484.
PMID: 34525183
Chimeric antigen receptor (CAR) T-cell toxicities resembling hemophagocytic lymphohistiocytosis (HLH) occur in a subset of patients with cytokine release syndrome (CRS). As a variant of conventional CRS, a comprehensive characterization...
8.
Huang Q, Birkett R, Doyle R, Haines G, Perlman H, Shi B, et al.
Arthritis Rheumatol
. 2017 May;
69(9):1762-1771.
PMID: 28511285
Objective: Macrophages are critical in the pathogenesis of rheumatoid arthritis (RA). We recently demonstrated that FLIP is necessary for the differentiation and/or survival of macrophages. We also showed that FLIP...
9.
Warner K, Homan P, Weeks K, Smith A, Abell C, Ferre-DAmare A
Chem Biol
. 2014 Apr;
21(5):591-5.
PMID: 24768306
Thiamine pyrophosphate (TPP) riboswitches regulate essential genes in bacteria by changing conformation upon binding intracellular TPP. Previous studies using fragment-based approaches identified small molecule "fragments" that bind this gene-regulatory mRNA...