Philip G Ashton-Rickardt
Overview
Explore the profile of Philip G Ashton-Rickardt including associated specialties, affiliations and a list of published articles.
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Articles
34
Citations
686
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Recent Articles
1.
Wang Y, Monteagudo A, Downey M, Ashton-Rickardt P, Elmaleh D
Sci Rep
. 2021 Apr;
11(1):8054.
PMID: 33850164
Cromolyn is a known mast cell stabilizer and is approved for treatment of asthma and for other allergic indications. Cromolyn, in a new redesigned dry powder formulation, is being tested...
2.
Shamji M, Layhadi J, Achkova D, Kouser L, Perera-Webb A, Couto-Francisco N, et al.
J Allergy Clin Immunol
. 2018 Jul;
143(3):1131-1142.e4.
PMID: 30053528
Background: Grass pollen-specific immunotherapy involves immunomodulation of allergen-specific T2 responses and induction of IL-10 and/or TGF-βCD4CD25 regulatory T cells (induced Treg cells). IL-35CD4CD25 forkhead box protein 3-negative T (IL-35-inducible regulatory...
3.
Ling G, Crawford G, Buang N, Bartok I, Tian K, Thielens N, et al.
Science
. 2018 May;
360(6388):558-563.
PMID: 29724957
Deficiency of C1q, the initiator of the complement classical pathway, is associated with the development of systemic lupus erythematosus (SLE). Explaining this association in terms of abnormalities in the classical...
4.
Ghosh S, Carmo M, Calero-Garcia M, Ricciardelli I, Ogando J, Blundell M, et al.
J Allergy Clin Immunol
. 2018 Jan;
142(3):904-913.e3.
PMID: 29355678
Background: Mutations in the perforin 1 (PRF1) gene account for up to 58% of familial hemophagocytic lymphohistiocytosis syndromes. The resulting defects in effector cell cytotoxicity lead to hypercytokinemia and hyperactivation...
5.
Shamji M, Temblay J, Cheng W, Byrne S, Macfarlane E, Switzer A, et al.
J Allergy Clin Immunol
. 2017 Nov;
142(2):569-581.e5.
PMID: 29106998
Background: The mechanisms that regulate maintenance of persistent T2 cells and potentiate allergic inflammation are not well understood. Objective: The function of serine protease inhibitor 2A (Spi2A) was studied in...
6.
Ashton-Rickardt P
Cell Metab
. 2016 Jun;
23(6):967-968.
PMID: 27304497
The development and function of cytotoxic CD8 T cells (CTLs), which provide immunity to viral infections, are regulated by changes in mitochondrial respiration. Champagne et al. (2016) describe a new...
7.
Okoye I, Wang L, Pallmer K, Richter K, Ichimura T, Haas R, et al.
Science
. 2015 Apr;
348(6238):995-1001.
PMID: 25883318
Protective CD8(+) T cell-mediated immunity requires a massive expansion in cell number and the development of long-lived memory cells. Using forward genetics in mice, we identified an orphan protein named...
8.
Kim M, Buisson L, Heathcote D, Hu H, Braddock D, Barrett A, et al.
Org Biomol Chem
. 2014 Oct;
12(44):8952-65.
PMID: 25277547
A structure-based design campaign for non-covalent small molecule inhibitors of human granzyme B was carried out by means of a virtual screening strategy employing three constraints and probe site-mapping with...
9.
Li L, Byrne S, Rainville N, Su S, Jachimowicz E, Aucher A, et al.
Stem Cells
. 2014 Jun;
32(9):2550-6.
PMID: 24964278
Prime regulation over hematopoietic progenitor cell (HPC) production is exerted by hematopoietins (HPs) and their Janus kinase-coupled receptors (HP-Rs). For HP/HP-R studies, one central challenge in determining specific effects involves...
10.
Salisbury E, Wang L, Choi O, Rutschmann S, Ashton-Rickardt P
Immunology
. 2014 Jan;
141(3):446-56.
PMID: 24383645
Natural regulatory T (nTreg) cells generated in the thymus are essential throughout life for the maintenance of T-cell homeostasis and the prevention of autoimmunity. T-cell receptor (TCR)/CD28-mediated activation of nuclear...