Petros A Tyrakis
Overview
Explore the profile of Petros A Tyrakis including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
749
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0
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Recent Articles
1.
Foskolou I, Cunha P, Sanchez-Lopez E, Minogue E, Nicolet B, Guislain A, et al.
Cell Rep
. 2023 Aug;
42(9):113013.
PMID: 37632752
2-Hydroxyglutarate (2HG) is a byproduct of the tricarboxylic acid (TCA) cycle and is readily detected in the tissues of healthy individuals. 2HG is found in two enantiomeric forms: S-2HG and...
2.
Sim J, Cowburn A, Palazon A, Madhu B, Tyrakis P, Macias D, et al.
Cell Metab
. 2018 Apr;
27(4):898-913.e7.
PMID: 29617647
Animals require an immediate response to oxygen availability to allow rapid shifts between oxidative and glycolytic metabolism. These metabolic shifts are highly regulated by the HIF transcription factor. The factor...
3.
Palazon A, Tyrakis P, Macias D, Velica P, Rundqvist H, Fitzpatrick S, et al.
Cancer Cell
. 2017 Nov;
32(5):669-683.e5.
PMID: 29136509
Cytotoxic T cells infiltrating tumors are thought to utilize HIF transcription factors during adaptation to the hypoxic tumor microenvironment. Deletion analyses of the two key HIF isoforms found that HIF-1α,...
4.
Tyrakis P, Yurkovich M, Sciacovelli M, Papachristou E, Bridges H, Gaude E, et al.
Cell Rep
. 2017 Oct;
21(4):1036-1047.
PMID: 29069586
Fumarate hydratase (FH) is an enzyme of the tricarboxylic acid (TCA) cycle mutated in hereditary and sporadic cancers. Despite recent advances in understanding its role in tumorigenesis, the effects of...
5.
Evans C, Palazon A, Sim J, Tyrakis P, Prodger A, Lu X, et al.
Biol Open
. 2017 Mar;
6(5):688-697.
PMID: 28302670
Thrombosis can cause localized ischemia and tissue hypoxia, and both of these are linked to cancer metastasis. Vascular micro-occlusion can occur as a result of arrest of circulating tumour cells...
6.
Phan A, Doedens A, Palazon A, Tyrakis P, Cheung K, Johnson R, et al.
Immunity
. 2016 Nov;
45(5):1024-1037.
PMID: 27836431
Extensive metabolic changes accompany T cell activation, including a switch to glycolytic energy production and increased biosynthesis. Recent studies suggest that subsequent return to reliance on oxidative phosphorylation and increasing...
7.
Tyrakis P, Palazon A, Macias D, Lee K, Phan A, Velica P, et al.
Nature
. 2016 Nov;
540(7632):236-241.
PMID: 27798602
R-2-hydroxyglutarate accumulates to millimolar levels in cancer cells with gain-of-function isocitrate dehydrogenase 1/2 mutations. These levels of R-2-hydroxyglutarate affect 2-oxoglutarate-dependent dioxygenases. Both metabolite enantiomers, R- and S-2-hydroxyglutarate, are detectible in...
8.
Yurkovich M, Tyrakis P, Hong H, Sun Y, Samborskyy M, Kamiya K, et al.
Chembiochem
. 2011 Nov;
13(1):66-71.
PMID: 22076845
No abstract available.