Petrilla Jayaprakash
Overview
Explore the profile of Petrilla Jayaprakash including associated specialties, affiliations and a list of published articles.
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20
Citations
207
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Recent Articles
1.
Eissa N, Jayaprakash P, Aljneibi S, Alsaadi A, Alzaabi S, Lazewska D, et al.
Eur J Pharmacol
. 2025 Mar;
997:177481.
PMID: 40058755
Accumulation of evidence suggested the involvement of autophagic pathways and their associated AktmTOR (mammalian target of rapamycin) signalling cascade in the pathogenesis of autism spectrum disorder (ASD). Histamine 3 receptors...
2.
Thomas S, Jayaprakash P, Marwan N, Aziz E, Kuder K, Lazewska D, et al.
Pharmaceuticals (Basel)
. 2024 Oct;
17(10).
PMID: 39458934
Background/objectives: Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by social interaction difficulties, repetitive behaviors, and immune dysregulation with elevated pro-inflammatory markers. Autophagic deficiency also contributes to social behavior...
3.
Jayaprakash P, Isaev D, Yang K, Beiram R, Oz M, Sadek B
Pharmaceuticals (Basel)
. 2024 Apr;
17(4).
PMID: 38675442
Studying the involvement of nicotinic acetylcholine receptors (nAChRs), specifically α7-nAChRs, in neuropsychiatric brain disorders such as autism spectrum disorder (ASD) has gained a growing interest. The flavonoid apigenin (APG) has...
4.
Abdalla S, Eissa N, Jayaprakash P, Beiram R, Kuder K, Lazewska D, et al.
Int J Mol Sci
. 2023 Aug;
24(16).
PMID: 37628900
The role of histamine H3 receptors (H3Rs) in memory and the prospective of H3R antagonists in pharmacological control of neurodegenerative disorders, e.g., Alzheimer's disease (AD), is well-accepted. Therefore, the procognitive...
5.
Nakhal M, Jayaprakash P, AbuRuz S, Sadek B, Akour A
Pharmaceuticals (Basel)
. 2023 May;
16(5).
PMID: 37242552
Based on their proven anti-inflammatory and antioxidant effects, recent studies have examined the therapeutic potential of the sodium-glucose cotransporter 2 (SGLT2) inhibitors in neurodevelopmental disorders such as autism spectrum disorder...
6.
Eissa N, Awad M, Thomas S, Venkatachalam K, Jayaprakash P, Zhong S, et al.
Int J Mol Sci
. 2023 Jan;
24(1).
PMID: 36613969
Dysregulation in brain neurotransmitters underlies several neuropsychiatric disorders, e.g., autism spectrum disorder (ASD). Also, abnormalities in the extracellular-signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) pathway pave the way for neuroinflammation, neurodegeneration,...
7.
Eissa N, Venkatachalam K, Jayaprakash P, Yuvaraju P, Falkenstein M, Stark H, et al.
Pharmaceuticals (Basel)
. 2022 Aug;
15(8).
PMID: 36015079
Altered regulation of neurotransmitters may lead to many pathophysiological changes in brain disorders including autism spectrum disorder (ASD). Given the fact that there are no FDA-approved effective treatments for the...
8.
Jayaprakash P, Isaev D, Shabbir W, Lorke D, Sadek B, Oz M
Int J Mol Sci
. 2021 Jul;
22(14).
PMID: 34298871
Autistic spectrum disorder (ASD) refers to a group of neurodevelopmental disorders characterized by impaired social interaction and cognitive deficit, restricted repetitive behaviors, altered immune responses, and imbalanced oxidative stress status....
9.
Venkatachalam K, Eissa N, Awad M, Jayaprakash P, Zhong S, Stolting F, et al.
Biomed Pharmacother
. 2021 Mar;
138:111517.
PMID: 33773463
Several brain neurotransmitters, including histamine (HA), acetylcholine (ACh), and dopamine (DA) are suggested to be involved in several brain disorders including cognitive deficits, depression, schizophrenia, anxiety, and narcolepsy, all of...
10.
Eissa N, Venkatachalam K, Jayaprakash P, Falkenstein M, Dubiel M, Frank A, et al.
Int J Mol Sci
. 2021 Mar;
22(4).
PMID: 33669336
Autism spectrum disorder (ASD) is a complex heterogeneous neurodevelopmental disorder characterized by social and communicative impairments, as well as repetitive and restricted behaviors (RRBs). With the limited effectiveness of current...