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Peter W Halcrow

Explore the profile of Peter W Halcrow including associated specialties, affiliations and a list of published articles. Areas
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Citations 147
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Recent Articles
1.
Afghah Z, Khan N, Datta G, Halcrow P, Geiger J, Chen X
Int J Mol Sci . 2024 Jun; 25(11). PMID: 38892390
Aurora kinase A (AURKA) is a serine/threonine-protein kinase that regulates microtubule organization during neuron migration and neurite formation. Decreased activity of AURKA was found in Alzheimer's disease (AD) brain samples,...
2.
Halcrow P, Quansah D, Kumar N, Solloway R, Teigen K, Lee K, et al.
NeuroImmune Pharm Ther . 2024 Mar; 3(1):33-46. PMID: 38532786
Objectives: Approximately 75 % of marketed drugs have the physicochemical property of being weak bases. Weak-base drugs with relatively high pK values enter acidic organelles including endosomes and lysosomes (endolysosomes),...
3.
Halcrow P, Quansah D, Kumar N, Steiner J, Nath A, Geiger J
J Neurosci . 2024 Feb; 44(14). PMID: 38383499
Human endogenous retroviruses (HERVs) are associated with the pathogenesis of amyotrophic lateral sclerosis (ALS); a disease characterized by motor neuron degeneration and cell death. The HERV-K subtype HML-2 envelope protein...
4.
Halcrow P, Kumar N, Hao E, Khan N, Meucci O, Geiger J
NeuroImmune Pharm Ther . 2023 Apr; 2(1):19-35. PMID: 37027339
Objectives: Opioids including morphine and DAMGO activate mu-opioid receptors (MOR), increase intracellular reactive oxygen species (ROS) levels, and induce cell death. Ferrous iron (Fe) through Fenton-like chemistry increases ROS levels...
5.
Halcrow P, Kumar N, Quansah D, Baral A, Liang B, Geiger J
Cells . 2022 Jun; 11(11). PMID: 35681506
People with human immunodeficiency virus-1 (PLWH) experience high rates of HIV-1-associated neurocognitive disorders (HANDs); clinical symptoms range from being asymptomatic to experiencing HIV-associated dementia. Antiretroviral therapies have effectively prolonged the...
6.
Halcrow P, Kumar N, Afghah Z, Fischer J, Khan N, Chen X, et al.
J Neurochem . 2022 Feb; 161(1):69-83. PMID: 35124818
Endolysosomes are key regulators of iron metabolism and are central to iron trafficking and redox signaling. Iron homeostasis is linked to endolysosome acidity and inhibition of endolysosome acidity triggers iron...
7.
Khan N, Halcrow P, Afghah Z, Baral A, Geiger J, Chen X
FASEB J . 2022 Feb; 36(3):e22184. PMID: 35113458
The presence of latent HIV-1 reservoirs in the periphery and brain represents a major obstacle to curing HIV-1 infection. As an essential protein for HIV-1 viral replication, HIV-1 Tat, mostly...
8.
Datta G, Miller N, Halcrow P, Khan N, Colwell T, Geiger J, et al.
Front Cell Neurosci . 2021 Nov; 15:777738. PMID: 34776872
SARS-CoV-2 is the viral cause of the COVID-19 pandemic. Increasingly, significant neurological disorders have been associated with COVID-19. However, the pathogenesis of these neurological disorders remains unclear especially because only...
9.
Khan N, Halcrow P, Lakpa L, Rehan M, Chen X, Geiger J
J Neurovirol . 2021 Sep; 27(5):755-773. PMID: 34550543
HIV-1 transactivator of transcription (Tat) protein is required for HIV-1 replication, and it has been implicated in the pathogenesis of HIV-1-associated neurocognitive disorder (HAND). HIV-1 Tat can enter cells via...
10.
Halcrow P, Lynch M, Geiger J, Ohm J
Semin Cancer Biol . 2021 Jun; 76:74-85. PMID: 34139350
Iron, the most abundant metal in human brain, is an essential microelement that regulates numerous cellular mechanisms. Some key physiological roles of iron include oxidative phosphorylation and ATP production, embryonic...