Peter Van Vlasselaer
Overview
Explore the profile of Peter Van Vlasselaer including associated specialties, affiliations and a list of published articles.
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7
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705
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Recent Articles
1.
Naing A, Wong D, Infante J, Korn W, Aljumaily R, Papadopoulos K, et al.
Lancet Oncol
. 2019 Sep;
20(11):1544-1555.
PMID: 31563517
Background: IL-10 has anti-inflammatory and CD8+ T-cell stimulating activities. Pegilodecakin (pegylated IL-10) is a first-in-class, long-acting IL-10 receptor agonist that induces oligoclonal T-cell expansion and has single-agent activity in advanced...
2.
Naing A, Infante J, Papadopoulos K, Chan I, Shen C, Ratti N, et al.
Cancer Cell
. 2018 Nov;
34(5):775-791.e3.
PMID: 30423297
Tumor-reactive T cell exhaustion prevents the success of immune therapies. Pegilodecakin activates intratumoral CD8 T cells in mice and induces objective tumor responses in patients. Here we report that pegilodecakin...
3.
Chan I, Wu V, Bilardello M, Jorgenson B, Bal H, McCauley S, et al.
Oncoimmunology
. 2016 Sep;
5(7):e1197458.
PMID: 27622052
IL-10 has been classically defined as a broad-spectrum immunosuppressant and is thought to facilitate the development of regulatory CD4(+) T cells. IL-10 is believed to represent one of the major...
4.
Naing A, Papadopoulos K, Autio K, Ott P, Patel M, Wong D, et al.
J Clin Oncol
. 2016 Aug;
34(29):3562-3569.
PMID: 27528724
Purpose Interleukin-10 (IL-10) stimulates the expansion and cytotoxicity of tumor-infiltrating CD8+ T cells and inhibits inflammatory CD4+ T cells. Pegylation prolongs the serum concentration of IL-10 without changing the immunologic...
5.
Chan I, Van Hoof D, Abramova M, Bilardello M, Mar E, Jorgensen B, et al.
PLoS One
. 2016 Jun;
11(6):e0156229.
PMID: 27299860
Interleukin-10 (IL-10) is a multifunctional cytokine that exerts potent context specific immunostimulatory and immunosuppressive effects. We have investigated the mechanism by which PEGylated rIL-10 regulates plasma cholesterol in mice and...
6.
Chan I, Wu V, Bilardello M, Mar E, Oft M, Van Vlasselaer P, et al.
J Interferon Cytokine Res
. 2015 Aug;
35(12):948-55.
PMID: 26309093
Interleukin-10 (IL-10) exerts both immunosuppressive and immunostimulatory effects. While the immunosuppressive effects are widely known, it has only been recently reported that pegylated recombinant human IL-10 (PEG-rHuIL-10) elicits potent interferon-γ...
7.
Barry-Hamilton V, Spangler R, Marshall D, McCauley S, Rodriguez H, Oyasu M, et al.
Nat Med
. 2010 Sep;
16(9):1009-17.
PMID: 20818376
We have identified a new role for the matrix enzyme lysyl oxidase-like-2 (LOXL2) in the creation and maintenance of the pathologic microenvironment of cancer and fibrotic disease. Our analysis of...