Peter V Simpson
Overview
Explore the profile of Peter V Simpson including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
130
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Recent Articles
1.
Bader C, Simpson P, Dallerba E, Stagni S, Johnson I, Hickey S, et al.
Dalton Trans
. 2024 Jan;
53(7):3407-3413.
PMID: 38269470
Morpholine motifs have been used extensively as targeting moieties for lysosomes, primarily in fluorescence imaging agents. Traditionally these imaging agents are based on organic molecules which have several shortcomings including...
2.
Muller V, Simpson P, Peng K, Basu U, Moreth D, Nagel C, et al.
Inorg Chem
. 2023 Sep;
62(39):16203-16214.
PMID: 37713601
The biological activity of Pd(II) and Pt(II) complexes toward three different cancer cell lines as well as inhibition of selenoenzyme thioredoxin reductase (TrxR) was modulated in an unexpected way by...
3.
Roemer M, Gillespie A, Jago D, Costa-Milan D, Alqahtani J, Hurtado-Gallego J, et al.
J Am Chem Soc
. 2022 Jun;
144(28):12698-12714.
PMID: 35767015
This paper describes the syntheses of several functionalized dihydropyrene (DHP) molecular switches with different substitution patterns. Regioselective nucleophilic alkylation of a 5-substituted dimethyl isophthalate allowed the development of a workable...
4.
Lazniewska J, Bader C, Hickey S, Selemidis S, OLeary J, Simpson P, et al.
Metallomics
. 2022 Jun;
14(8).
PMID: 35657681
Cholesterol is vital to control membrane integrity and fluidity, but is also a precursor to produce steroid hormones, bile acids, and vitamin D. Consequently, altered cholesterol biology has been linked...
5.
Paternoster S, Simpson P, Kokh E, Kizilkaya H, Rosenkilde M, Mancera R, et al.
Pharmacol Res
. 2021 Aug;
172:105822.
PMID: 34411732
Metabolic diseases, such as obesity and type 2 diabetes, are relentlessly spreading worldwide. The beginning of the 21st century has seen the introduction of mechanistically novel types of drugs, aimed...
6.
Domenichini A, Casari I, Simpson P, Desai N, Chen L, Dustin C, et al.
J Exp Clin Cancer Res
. 2020 Dec;
39(1):276.
PMID: 33287862
Background: Platinum-based anticancer drugs have been at the frontline of cancer therapy for the last 40 years, and are used in more than half of all treatments for different cancer...
7.
Nicholls T, Burt L, Simpson P, Massi M, Bissember A
Dalton Trans
. 2019 Aug;
48(33):12749-12754.
PMID: 31389462
We have investigated the capacity of a range of structurally-diverse, photoactive rhenium(i) tricarbonyl complexes featuring either tetrazolato or N-heterocyclic carbene (NHC) ligands to facilitate fundamental classes of visible-light-mediated photoredox-catalysed reactions....
8.
Simpson P, Desai N, Casari I, Massi M, Falasca M
Future Med Chem
. 2019 Jan;
11(2):119-135.
PMID: 30644327
Despite improvements in the 5-year survival rate to over 80% in cancers, such as Hodgkin lymphoma and testicular cancer, more aggressive tumors including pancreatic and brain cancer still have extremely...
9.
Sorvina A, Bader C, Caporale C, Carter E, Johnson I, Parkinson-Lawrence E, et al.
Oncotarget
. 2018 Nov;
9(85):35541-35552.
PMID: 30473749
Lipids are important cellular components which can be significantly altered in a range of disease states including prostate cancer. Here, a unique systematic approach has been used to define lipid...
10.
Simpson P, Falasca M, Massi M
Chem Commun (Camb)
. 2018 Oct;
54(88):12429-12438.
PMID: 30302483
Re(i) complexes bound to π-conjugated bidentate N-heterocyclic carbene ligands with formulation Re(CO)3(N^NHC)L (where N^NHC represents an imidazole or benzimidazole carbene ligand conjugated to a N-based heterocycle such as pyridine, pyrimidine,...