Peter R W Gowler
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Explore the profile of Peter R W Gowler including associated specialties, affiliations and a list of published articles.
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10
Citations
96
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Recent Articles
1.
Gowler P, Arendt-Tranholm A, Turnbull J, Jha R, Onion D, Kelly T, et al.
iScience
. 2025 Feb;
28(2):111862.
PMID: 39995860
Our goal was to probe the potential transcriptomic basis for the relationship between plasma levels of the specialized pro-resolving precursor, 17-hydroxy-docosahexaenoic acid (17-HDHA) and chronic pain. Participants with osteoarthritis (average...
2.
Turnbull J, Jha R, Gowler P, Ferrands-Bentley R, Kim D, Barrett D, et al.
Osteoarthritis Cartilage
. 2024 Apr;
32(8):990-1000.
PMID: 38648876
Objective: To examine associations between serum oxylipins, which regulate tissue repair and pain signalling, and knee pain/radiographic osteoarthritis (OA) at baseline and knee pain at 3 year follow-up. Method: Baseline,...
3.
Gowler P, Turnbull J, Shahtaheri M, Walsh D, Barrett D, Chapman V
Eur J Pain
. 2022 Sep;
26(10):2213-2226.
PMID: 36097797
Background: Synovial inflammation has known contributions to chronic osteoarthritis (OA) pain, but the potential role in transitions from early to late stages of OA pain is unclear. Methods: The slowly...
4.
Goncalves S, Gowler P, Woodhams S, Turnbull J, Hathway G, Chapman V
Neuropharmacology
. 2022 May;
213:109075.
PMID: 35490907
Osteoarthritis (OA) is a chronic joint disease that represents an increasingly substantial global burden. Joint pain is the most significant symptom of OA. Unfortunately, current pharmacological treatments for OA pain...
5.
Lillywhite A, Woodhams S, Goncalves S, Watson D, Li L, Burston J, et al.
Pain Rep
. 2022 Feb;
6(4):e956.
PMID: 35128295
Introduction: Negative affect, including anxiety and depression, is prevalent in chronic pain states such as osteoarthritis (OA) and associated with greater use of opioid analgesics, potentially contributing to present and...
6.
Clinical and Preclinical Evidence for Roles of Soluble Epoxide Hydrolase in Osteoarthritis Knee Pain
Gowler P, Turnbull J, Shahtaheri M, Gohir S, Kelly T, McReynolds C, et al.
Arthritis Rheumatol
. 2021 Oct;
74(4):623-633.
PMID: 34672113
Objective: Chronic pain due to osteoarthritis (OA) is a major clinical problem, and existing analgesics often have limited beneficial effects and/or adverse effects, necessitating the development of novel therapies. Epoxyeicosatrienoic...
7.
Gowler P, Mapp P, Burston J, Shahtaheri M, Walsh D, Chapman V
PLoS One
. 2020 Sep;
15(9):e0239663.
PMID: 32991618
The relationship between osteoarthritis (OA) structural change and pain is complex. Surgical models of OA in rodents are often rapid in onset, limiting mechanistic utility and translational validity. We aimed...
8.
Gowler P, Li L, Woodhams S, Bennett A, Suzuki R, Walsh D, et al.
Pain
. 2019 Sep;
161(1):61-73.
PMID: 31479064
Brain-derived neurotrophic factor (BDNF) and the high-affinity receptor tropomyosin receptor kinase B (TrkB) have important roles in neuronal survival and in spinal sensitization mechanisms associated with chronic pain. Recent clinical...
9.
Woodhams S, Markus R, Gowler P, Self T, Chapman V
Pain
. 2019 Aug;
160(11):2641-2650.
PMID: 31425488
Spinal hyperexcitability is a key event in the development of persistent pain, and arises partly from alterations in the number and localization of α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)-type glutamate receptors. However, determining...
10.
Burston J, Valdes A, Woodhams S, Mapp P, Stocks J, Watson D, et al.
Pain
. 2019 Feb;
160(3):658-669.
PMID: 30779717
Anxiety and depression are associated with increased pain responses in chronic pain states. The extent to which anxiety drives chronic pain, or vice versa, remains an important question that has...