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Peter Metrakos

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Articles 121
Citations 2913
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Recent Articles
1.
Meunier A, Hernandez-Castro J, Chahley N, Communal L, Kheireddine S, Koushki N, et al.
Commun Med (Lond) . 2025 Feb; 5(1):33. PMID: 39900650
Background: Circulating tumor cells (CTCs) are rare (a few cells per milliliter of blood) and mostly isolated as single-cell CTCs (scCTCs). CTC clusters (cCTCs), even rarer, are of growing interest,...
2.
Tsamchoe M, Lazaris A, Kim D, Krzywon L, Bloom J, Mayer T, et al.
BJC Rep . 2024 Nov; 1(1):8. PMID: 39516397
Background: Metastasis is the principal cause of cancer treatment failure and an area of dire diagnostic needs. Colorectal cancer metastases to the liver (CRCLMs) are predominantly classified into desmoplastic and...
3.
Kalil J, Krzywon L, Petrillo S, Tsamchoe M, Zlotnik O, Lazaris A, et al.
Front Oncol . 2024 Oct; 14:1418696. PMID: 39439963
Introduction: Approximately 50% of patients diagnosed with colorectal cancer develop colorectal cancer liver metastases (CRLM). Although curative intent liver resection provides 5-year survival of 40-50%, up to 70% of patients...
4.
Krzywon L, Lazaris A, Petrillo S, Zlotnik O, Gao Z, Metrakos P
Cancers (Basel) . 2024 Sep; 16(18). PMID: 39335120
Introduction: Colorectal cancer liver metastasis (CRCLM) remains a lethal diagnosis, with an overall 5-year survival rate of 5-10%. Two distinct histopathological growth patterns (HGPs) of CRCLM are known to have...
5.
Karanicolas P, Lin Y, McCluskey S, Tarshis J, Thorpe K, Wei A, et al.
JAMA . 2024 Aug; 332(13):1080-1089. PMID: 39158894
Importance: Tranexamic acid reduces bleeding and blood transfusion in many types of surgery, but its effect in patients undergoing liver resection for a cancer-related indication remains unclear. Objective: To determine...
6.
Kalil J, Deschenes M, Perrier H, Zlotnik O, Metrakos P
Biomedicines . 2024 Jun; 12(6). PMID: 38927471
This review explores the intricacies of evaluating cirrhotic patients for liver resection while exploring how to extend surgical intervention to those typically excluded by the Barcelona Clinic Liver Cancer (BCLC)...
7.
Li Y, Chen L, Sottas C, Raul M, Patel N, Bijja J, et al.
Metabolism . 2024 Jun; 159:155942. PMID: 38871077
Background And Aims: The mitochondrial translocator protein (TSPO, 18 kDa) is pivotal in binding cholesterol and facilitating its transfer from the outer to the inner mitochondrial membrane. Atriol is a...
8.
Kalil J, Krzywon L, Zlotnik O, Perrier H, Petrillo S, Chaudhury P, et al.
Cancers (Basel) . 2024 May; 16(9). PMID: 38730684
(1) Background: Despite advances in surgical technique and systemic chemotherapy, some patients with multifocal, bilobar colorectal liver metastases (CRLM) remain unresectable. These patients may benefit from surgical debulking of liver...
9.
Korenblik R, Heil J, Smits J, James S, Olij B, Bechstein W, et al.
Br J Surg . 2024 Apr; 111(4). PMID: 38662462
Background: The purpose of this study was to compare 3-year overall survival after simultaneous portal (PVE) and hepatic vein (HVE) embolization versus PVE alone in patients undergoing liver resection for...
10.
Zlotnik O, Krzywon L, Bloom J, Kalil J, Altubi I, Lazaris A, et al.
Cancers (Basel) . 2023 Nov; 15(21). PMID: 37958384
Immunotherapy has revolutionized the treatment of several cancers, including melanoma and lung cancer. However, for colorectal cancer, it is ineffective for 95% of patients with microsatellite-stable disease. Recent evidence suggests...