Peter K Nicholls
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Explore the profile of Peter K Nicholls including associated specialties, affiliations and a list of published articles.
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29
Citations
709
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Recent Articles
1.
Loehr A, Timmerman D, Liu M, Gillis A, Matthews M, Bloom J, et al.
Sci Rep
. 2025 Feb;
15(1):4452.
PMID: 39910147
Malignant testicular germ cells tumors (TGCTs) are the most common solid cancers in young men. Current TGCT diagnostics include conventional serum protein markers, but these lack the sensitivity and specificity...
2.
Loehr A, Timmerman D, Liu M, Gillis A, Matthews M, Bloom J, et al.
bioRxiv
. 2023 Sep;
PMID: 37745561
Malignant testicular germ cells tumors (TGCTs) are the most common solid cancers in young men. Current TGCT diagnostics include conventional serum protein markers, but these lack the sensitivity and specificity...
3.
Fonseca A, Lobo J, Hazard F, Gell J, Nicholls P, Weiss R, et al.
Br J Cancer
. 2022 Oct;
127(9):1577-1583.
PMID: 36229581
Germ cell tumours (GCTs) are a heterogeneous group of rare neoplasms that present in different anatomical sites and across a wide spectrum of patient ages from birth through to adulthood....
4.
Hughes J, Skaletsky H, Nicholls P, Drake A, Pyntikova T, Cho T, et al.
BMC Biol
. 2022 Jun;
20(1):133.
PMID: 35676717
Background: The mammalian X and Y chromosomes originated from a pair of ordinary autosomes. Over the past ~180 million years, the X and Y have become highly differentiated and now...
5.
Nicholls P, Page D
Development
. 2021 Apr;
148(8).
PMID: 33913479
In each generation, the germline is tasked with producing somatic lineages that form the body, and segregating a population of cells for gametogenesis. During animal development, when do cells of...
6.
Mikedis M, Fan Y, Nicholls P, Endo T, Jackson E, Cobb S, et al.
Elife
. 2020 Jul;
9.
PMID: 32686646
Fertility across metazoa requires the germline-specific DAZ family of RNA-binding proteins. Here we examine whether DAZL directly regulates progenitor spermatogonia using a conditional genetic mouse model and in vivo biochemical...
7.
Dokshin G, Davis G, Sawle A, Eldridge M, Nicholls P, Gourley T, et al.
Dev Cell
. 2019 Dec;
52(1):53-68.e6.
PMID: 31839538
GCNA proteins are expressed across eukarya in pluripotent cells and have conserved functions in fertility. GCNA homologs Spartan (DVC-1) and Wss1 resolve DNA-protein crosslinks (DPCs), including Topoisomerase-DNA adducts, during DNA...
8.
Endo T, Mikedis M, Nicholls P, Page D, de Rooij D
Biomolecules
. 2019 Nov;
9(12).
PMID: 31771306
Retinoic acid (RA), a derivative of vitamin A, is critical for the production of oocytes and sperm in mammals. These gametes derive from primordial germ cells, which colonize the nascent...
9.
Nicholls P, Schorle H, Naqvi S, Hu Y, Fan Y, Carmell M, et al.
Proc Natl Acad Sci U S A
. 2019 Nov;
116(51):25677-25687.
PMID: 31754036
Mammalian primordial germ cells (PGCs) are induced in the embryonic epiblast, before migrating to the nascent gonads. In fish, frogs, and birds, the germline segregates even earlier, through the action...
10.
Nicholls P, Bellott D, Cho T, Pyntikova T, Page D
G3 (Bethesda)
. 2019 Mar;
9(5):1481-1486.
PMID: 30837263
The introduction of foreign DNA into cells and organisms has facilitated much of modern biological research, and it promises to become equally important in clinical practice. Locating sites of foreign...