Peter J OToole
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Explore the profile of Peter J OToole including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
200
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Recent Articles
1.
Wiggins L, OToole P, Brackenbury W, Wilson J
Microsc Res Tech
. 2024 Nov;
88(3):716-731.
PMID: 39548933
Segmentation and tracking are essential preliminary steps in the analysis of almost all live cell imaging applications. Although the number of open-source software systems that facilitate automated segmentation and tracking...
2.
Xelhuantzi M, Ghete D, Milburn A, Ioannou S, Mudd P, Calder G, et al.
Biol Open
. 2024 Jul;
13(7).
PMID: 39078271
Although some budding yeasts have proved tractable and intensely studied models, others are more recalcitrant. Debaryomyces hansenii, an important yeast species in food and biotechnological industries with curious physiological characteristics,...
3.
OToole P, Marrison J
J Microsc
. 2023 Nov;
294(3):372-379.
PMID: 37973413
Here we outline a vignette of the Bioscience Technology Facility (BTF) at the University of York as a singular exemplar of the Full Cost Recovery model. It is fully appreciated...
4.
Wiggins L, Lord A, Murphy K, Lacy S, OToole P, Brackenbury W, et al.
Nat Commun
. 2023 Apr;
14(1):1854.
PMID: 37012230
With phenotypic heterogeneity in whole cell populations widely recognised, the demand for quantitative and temporal analysis approaches to characterise single cell morphology and dynamics has increased. We present CellPhe, a...
5.
Laidlaw K, Paine K, Bisinski D, Calder G, Hogg K, Ahmed S, et al.
Mol Biol Cell
. 2022 Jan;
33(4):ar31.
PMID: 35080991
Cell surface protein trafficking is regulated in response to nutrient availability, with multiple pathways directing surface membrane proteins to the lysosome for degradation in response to suboptimal extracellular nutrients. Internalized...
6.
Dindo M, Ambrosini G, Oppici E, Pey A, OToole P, Marrison J, et al.
J Pers Med
. 2021 Apr;
11(4).
PMID: 33917320
Peroxisomal matrix proteins are transported into peroxisomes in a fully-folded state, but whether multimeric proteins are imported as monomers or oligomers is still disputed. Here, we used alanine:glyoxylate aminotransferase (AGT),...
7.
Stanly T, Suman R, Rani G, OToole P, Kaye P, Hitchcock I
Front Physiol
. 2020 Oct;
11:568087.
PMID: 33041864
Platelets are specialized anucleate cells that play a major role in hemostasis following vessel injury. More recently, platelets have also been implicated in innate immunity and inflammation by directly interacting...
8.
Wise D, Gamble A, Arkawazi S, Walton P, Galan M, OHagan M, et al.
Dalton Trans
. 2020 Oct;
49(43):15219-15230.
PMID: 33021299
We report cytotoxic ruthenium(ii) complexes of the general formula [RuCl(cis-tach)(diphosphine)]+ (cis-tach = cis-cis-1,3,5-triaminocyclohexane) that have been characterised by 1H, 13C and 31P{1H} NMR spectroscopy, mass spectrometry, X-ray crystallography and elemental...
9.
Simon A, Yang M, Marrison J, James A, Hunt M, OToole P, et al.
J Neuroinflammation
. 2020 Mar;
17(1):87.
PMID: 32192526
Background: An emerging problem in the treatment of breast cancer is the increasing incidence of metastases to the brain. Metastatic brain tumours are incurable and can cause epileptic seizures and...
10.
Yang M, James A, Suman R, Kasprowicz R, Nelson M, OToole P, et al.
J Cell Physiol
. 2019 Oct;
235(4):3950-3972.
PMID: 31612502
Ion channels can regulate the plasma membrane potential (V ) and cell migration as a result of altered ion flux. However, the mechanism by which V regulates motility remains unclear....