Peter Fedorocko
Overview
Explore the profile of Peter Fedorocko including associated specialties, affiliations and a list of published articles.
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67
Citations
507
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Recent Articles
1.
Bulkova V, Vargova J, Babincak M, Jendzelovsky R, Zdrahal Z, Roudnicky P, et al.
Biomed Pharmacother
. 2023 May;
163:114829.
PMID: 37146419
The presence of key hypoxia regulators, namely, hypoxia-inducible factor (HIF)-1α or HIF-2α, in tumors is associated with poor patient prognosis. Hypoxia massively activates several genes, including the one encoding the...
2.
Majernik M, Jendzelovsky R, Vargova J, Jendzelovska Z, Fedorocko P
Pharmaceutics
. 2022 May;
14(5).
PMID: 35631660
It is more than sixty years since the era of modern photodynamic therapy (PDT) for cancer began. Enhanced selectivity for malignant cells with a reduced selectivity for non-malignant cells and...
3.
Vilkova M, Hudacova M, Palusekova N, Jendzelovsky R, Almasi M, Beres T, et al.
Molecules
. 2022 May;
27(9).
PMID: 35566236
A series of novel acridine N-acylhydrazone derivatives have been synthesized as potential topoisomerase I/II inhibitors, and their binding (calf thymus DNA—ctDNA and human serum albumin—HSA) and biological activities as potential...
4.
Hudacova M, Hamulakova S, Konkolova E, Jendzelovsky R, Vargova J, Sevc J, et al.
Int J Mol Sci
. 2021 Apr;
22(8).
PMID: 33917200
A series of novel C4-C7-tethered biscoumarin derivatives (-) linked through piperazine moiety was designed, synthesized, and evaluated biological/therapeutic potential. Biscoumarin was found to be the most effective inhibitor of both...
5.
Babincak M, Jendzelovsky R, Kosuth J, Majernik M, Vargova J, Mikulasek K, et al.
Cancers (Basel)
. 2021 Apr;
13(7).
PMID: 33916015
Skyrin (SKR) is a plant bisanthraquinone secondary metabolite from the genus with potential use in anticancer therapy. However, its effect and mechanism of action are still unknown. The negative effect...
6.
Konkolova E, Hudacova M, Hamulakova S, Jendzelovsky R, Vargova J, Sevc J, et al.
Molecules
. 2021 Mar;
26(4).
PMID: 33672694
A549 human lung carcinoma cell lines were treated with a series of new drugs with both tacrine and coumarin pharmacophores (derivatives -) in order to test the compounds' ability to...
7.
Majernik M, Jendzelovsky R, Fedorocko P
Cancers (Basel)
. 2020 Aug;
12(8).
PMID: 32751731
The relevance of experimentally gained information represents a long-term debating issue in the field of molecular biology research. The loss of original conditions in the in vitro environment affects various...
8.
Macejova M, Sackova V, Hradicka P, Jendzelovsky R, Demeckova V, Fedorocko P
Toxicol In Vitro
. 2020 Apr;
66:104860.
PMID: 32298799
The use of natural products as chemotherapeutic agents and tools for manipulation of apoptosis represent an attractive therapeutic concept. In this study, we investigated the anticancer activities of a combination...
9.
Suvakova M, Majernik M, Jendzelovsky R, Hovan A, Bano G, Fedorocko P, et al.
J Photochem Photobiol B
. 2020 Mar;
206:111855.
PMID: 32220773
Hypericin (HY) is a naphthodianthrone that naturally occurs in Hypericum perforatum L. It is a promising photosensitiser used in photodynamic therapy for and diagnosis of oncological diseases. However, its hydrophobic...
10.
Nunhart P, Konkolova E, Janovec L, Jendzelovsky R, Vargova J, Sevc J, et al.
Bioorg Chem
. 2019 Nov;
94:103393.
PMID: 31679839
A series of new 3,6,9-trisubstituted acridine derivatives with fluorine substituents on phenyl ring were synthesized and their interaction with calf thymus DNA was investigated. Analysis using UV-Vis absorbance spectra provided...