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Peter Bryan

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Articles 8
Citations 43
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Recent Articles
1.
Patel S, Barricklow J, Bryan P, Rospo C, Spooner N, Wang M, et al.
AAPS J . 2024 Oct; 26(6):110. PMID: 39424658
The implementation of microsampling approaches for use in nonclinical discovery and development pharmaceutical studies can have a major impact on improving animal ethics through the use of fewer animals and...
2.
Tao L, Jeong D, Wang J, Adams Z, Bryan P, Levin C
Phys Med Biol . 2020 Jul; 65(21):215021. PMID: 32707569
The concept of using the modulation mechanisms of a material's optical properties for annihilation photon detection has been proposed as a potential method to significantly improve the coincidence time resolution...
3.
Patel S, Bryan P, Spooner N, Timmerman P, Wickremsinhe E
Bioanalysis . 2019 Apr; 11(7):619-628. PMID: 30973016
There is continuing interest in the development and application of various microsampling technologies for drug development. The AAPS bioanalytical community microsampling subgroup and the European Bioanalysis Forum conducted a survey...
4.
Fung E, Bryan P, Kozhich A
Bioanalysis . 2016 Mar; 8(8):847-56. PMID: 27005854
LC-MS/MS has been investigated to quantify protein therapeutics in biological matrices. The protein therapeutics is digested by an enzyme to generate surrogate peptide(s) before LC-MS/MS analysis. One challenge is isolating...
5.
Evans C, Arnold M, Bryan P, Duggan J, James C, Li W, et al.
AAPS J . 2014 Dec; 17(2):292-300. PMID: 25488054
No abstract available.
6.
Chen N, Chawla S, Chiorean E, Read W, Gorbaty M, Mita A, et al.
Cancer Chemother Pharmacol . 2013 Feb; 71(4):1083-94. PMID: 23400695
Purpose: To evaluate the pharmacokinetics and cardiac repolarization effect (measured by QT/QTc interval) of amrubicin and its active metabolite amrubicinol in non-Japanese patients with advanced solid tumors. Methods: Patients received...
7.
Appleton T, Bryan P, Contos D, Henry T, Lehmann P, Ohorodnik S, et al.
AAPS J . 2012 May; 14(3):523-9. PMID: 22566150
Nonclinical safety studies are required to follow applicable Good Laboratory Practice (GLP) regulations. Nonclinical dose formulations are required to be analyzed to confirm the analyte concentration, homogeneity, and stability. Analytical...
8.
Whitmire M, Bryan P, Henry T, Holbrook J, Lehmann P, Mollitor T, et al.
AAPS J . 2010 Aug; 12(4):628-34. PMID: 20711763
Nonclinical dose formulation analysis methods are used to confirm test article concentration and homogeneity in formulations and determine formulation stability in support of regulated nonclinical studies. There is currently no...