Peter Brouckaert
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Explore the profile of Peter Brouckaert including associated specialties, affiliations and a list of published articles.
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84
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1446
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Recent Articles
11.
Decaluwe K, Pauwels B, Boydens C, Thoonen R, Buys E, Brouckaert P, et al.
J Sex Med
. 2017 Feb;
14(2):196-204.
PMID: 28161078
Introduction: The nitric oxide (NO), soluble guanylate cyclase (sGC), and cyclic guanosine monophosphate (cGMP) pathway is the leading pathway in penile erection. Aim: To assess erectile function in a mouse...
12.
Sips M, Liu Q, Draghi M, Ghebremichael M, Berger C, Suscovich T, et al.
Hum Immunol
. 2016 Aug;
77(12):1147-1153.
PMID: 27521484
Differences in HLA-C expression are inversely correlated with HIV viral load set-point and slower progression to AIDS, linked to enhanced cytotoxic T cell immunity. Yet, beyond T cells, HLA-C serves...
13.
De Pauw A, Massion P, Sekkali B, Andre E, Dubroca C, Kmecova J, et al.
Cardiovasc Res
. 2016 Aug;
112(1):478-90.
PMID: 27520736
Aim: Cardiac progenitor cells (CPC) from adult hearts can differentiate to several cell types composing the myocardium but the underlying molecular pathways are poorly characterized. We examined the role of...
14.
Vandenwijngaert S, Swinnen M, Walravens A, Beerens M, Gillijns H, Caluwe E, et al.
Antioxid Redox Signal
. 2016 Aug;
26(4):153-164.
PMID: 27505125
Aims: The use of doxorubicin, a potent chemotherapeutic agent, is limited by cardiotoxicity. We tested the hypothesis that decreased soluble guanylate cyclase (sGC) enzyme activity contributes to the development of...
15.
Hobai I, Aziz K, Buys E, Brouckaert P, Siwik D, Colucci W
Shock
. 2016 Jul;
46(6):713-722.
PMID: 27405063
In male mice, sepsis-induced cardiomyopathy develops as a result of dysregulation of myocardial calcium (Ca) handling, leading to depressed cellular Ca transients (ΔCai). ΔCai depression is partially due to inhibition...
16.
Moon Y, Balke J, Madorma D, Siegel M, Knowels G, Brouckaert P, et al.
Antioxid Redox Signal
. 2016 Jul;
26(17):966-985.
PMID: 27393340
Aim: Skeletal muscle nitric oxide-cyclic guanosine monophosphate (NO-cGMP) pathways are impaired in Duchenne and Becker muscular dystrophy partly because of reduced nNOSμ and soluble guanylate cyclase (GC) activity. However, GC...
17.
Dordea A, Vandenwijngaert S, Garcia V, Tainsh R, Nathan D, Allen K, et al.
Am J Physiol Heart Circ Physiol
. 2016 May;
310(11):H1790-800.
PMID: 27199131
Dysregulated nitric oxide (NO) signaling contributes to the pathogenesis of hypertension, a prevalent and often sex-specific risk factor for cardiovascular disease. We previously reported that mice deficient in the α1-subunit...
18.
Thoonen R, Cauwels A, Decaluwe K, Geschka S, Tainsh R, Delanghe J, et al.
Nat Commun
. 2015 Oct;
6:8482.
PMID: 26442659
Oxidative stress, a central mediator of cardiovascular disease, results in loss of the prosthetic haem group of soluble guanylate cyclase (sGC), preventing its activation by nitric oxide (NO). Here we...
19.
Hultberg A, Morello V, Huyghe L, De Jonge N, Blanchetot C, Hanssens V, et al.
Cancer Res
. 2015 Jul;
75(16):3373-83.
PMID: 26141862
Hepatocyte growth factor (HGF) and its receptor MET represent validated targets for cancer therapy. However, HGF/MET inhibitors being explored as cancer therapeutics exhibit cytostatic activity rather than cytotoxic activity, which...
20.
Wijnands K, Meesters D, van Barneveld K, Visschers R, Briede J, Vandendriessche B, et al.
Nutrients
. 2015 Jul;
7(7):5217-38.
PMID: 26132994
Enhanced arginase-induced arginine consumption is believed to play a key role in the pathogenesis of sickle cell disease-induced end organ failure. Enhancement of arginine availability with L-arginine supplementation exhibited less...