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Peter A Simpson

Explore the profile of Peter A Simpson including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 5
Citations 219
Followers 0
Related Specialties
Cardiology & Vascular Diseases
Biochemistry
Top 10 Co-Authors
Mary C M Weiser-Evans
Raphael A Nemenoff
Seth B Furgeson
Vicki VanPutten
Henrick Horita
Joseph Crossno
Christopher D Kontos
Pamela J Garl
Henrick N Horita
Fred S Apple
Published In
Arterioscler Thromb Vasc Biol
Circ Res
Cardiovasc Res
Clin Biochem
Affiliations
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Recent Articles
1.
Serum response factor regulates expression of phosphatase and tensin homolog through a microRNA network in vascular smooth muscle cells
Horita H, Simpson P, Ostriker A, Furgeson S, Van Putten V, Weiser-Evans M, et al.
Arterioscler Thromb Vasc Biol . 2011 Sep; 31(12):2909-19. PMID: 21940949
Objective: Serum response factor (SRF) is a critical transcription factor in smooth muscle cells (SMCs) controlling differentiation and proliferation. Our previous work demonstrated that depleting SRF in cultured SMCs decreased...
2.
SDF-1α induction in mature smooth muscle cells by inactivation of PTEN is a critical mediator of exacerbated injury-induced neointima formation
Nemenoff R, Horita H, Ostriker A, Furgeson S, Simpson P, VanPutten V, et al.
Arterioscler Thromb Vasc Biol . 2011 Mar; 31(6):1300-8. PMID: 21415388
Objective: PTEN inactivation selectively in smooth muscle cells (SMC) initiates multiple downstream events driving neointima formation, including SMC cytokine/chemokine production, in particular stromal cell-derived factor-1α (SDF-1α). We investigated the effects...
3.
Defining the serum 99th percentile in a normal reference population measured by a high-sensitivity cardiac troponin I assay
Apple F, Simpson P, Murakami M
Clin Biochem . 2010 Jun; 43(12):1034-6. PMID: 20510894
Objectives: This study determined the serum 99th percentile reference value for cTnI measured using the high sensitivity Erenna cTnI assay. Design And Methods: Serum was obtained from healthy adults (n=348);...
4.
Inactivation of the tumour suppressor, PTEN, in smooth muscle promotes a pro-inflammatory phenotype and enhances neointima formation
Furgeson S, Simpson P, Park I, VanPutten V, Horita H, Kontos C, et al.
Cardiovasc Res . 2010 Jan; 86(2):274-82. PMID: 20051384
Aims: Phosphatase and tensin homolog (PTEN) is implicated as a negative regulator of vascular smooth muscle cell (SMC) proliferation and injury-induced vascular remodelling. We tested if selective depletion of PTEN...
5.
Targeted deletion of PTEN in smooth muscle cells results in vascular remodeling and recruitment of progenitor cells through induction of stromal cell-derived factor-1alpha
Nemenoff R, Simpson P, Furgeson S, Kaplan-Albuquerque N, Crossno J, Garl P, et al.
Circ Res . 2008 Mar; 102(9):1036-45. PMID: 18340011
We previously showed that changes in vascular smooth muscle cell (SMC) PTEN/Akt signaling following vascular injury are associated with increased SMC proliferation and neointima formation. In this report, we used...