Pengxiang Huang
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Explore the profile of Pengxiang Huang including associated specialties, affiliations and a list of published articles.
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25
Citations
1956
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Recent Articles
11.
Li Q, Qian J, Li Y, Huang P, Liang H, Sun H, et al.
Free Radic Biol Med
. 2020 Aug;
159:136-149.
PMID: 32738398
Background: Nonalcoholic fatty liver (NAFL) is emerging as a leading risk factor of hepatic ischemia/reperfusion (I/R) injury lacking of effective therapy. Lipid dyshomeostasis has been implicated in the hepatopathy of...
12.
Huang P, Zheng S, Wierbowski B, Kim Y, Nedelcu D, Aravena L, et al.
Cell
. 2018 Sep;
175(1):295-297.
PMID: 30241610
No abstract available.
13.
Huang P, Zheng S, Wierbowski B, Kim Y, Nedelcu D, Aravena L, et al.
Cell
. 2018 May;
174(2):312-324.e16.
PMID: 29804838
The seven-transmembrane-spanning protein Smoothened is the central transducer in Hedgehog signaling, a pathway fundamental in development and in cancer. Smoothened is activated by cholesterol binding to its extracellular cysteine-rich domain...
14.
Huang P, Nedelcu D, Watanabe M, Jao C, Kim Y, Liu J, et al.
Cell
. 2016 Aug;
166(5):1176-1187.e14.
PMID: 27545348
In vertebrates, sterols are necessary for Hedgehog signaling, a pathway critical in embryogenesis and cancer. Sterols activate the membrane protein Smoothened by binding its extracellular, cysteine-rich domain (CRD). Major unanswered...
15.
Liao M, Su S, Yan K, Zhu X, Huang P, Li J, et al.
AIDS Behav
. 2015 Dec;
20(3):655-66.
PMID: 26696263
Eight consecutive annual cross-sectional surveys were conducted to examine the trend of the prevalence of HIV, syphilis, drug use and their correlates among female sex workers (FSWs) in Qingdao, China....
16.
Liao M, Wang M, Shen X, Huang P, Yang X, Hao L, et al.
PLoS One
. 2015 Jun;
10(6):e0130866.
PMID: 26121250
Objective: To assess the correlates for bisexual behaviors, HIV knowledge, and HIV/AIDS-related stigmatizing/discriminatory attitudes among men who have sex with men (MSM). Methods: A cross-sectional survey among MSM was conducted...
17.
Santori F, Huang P, van de Pavert S, Douglass Jr E, Leaver D, Haubrich B, et al.
Cell Metab
. 2015 Feb;
21(2):286-298.
PMID: 25651181
Mice deficient in the nuclear hormone receptor RORγt have defective development of thymocytes, lymphoid organs, Th17 cells, and type 3 innate lymphoid cells. RORγt binds to oxysterols derived from cholesterol...
18.
Huang P, Chandra V, Rastinejad F
Chem Rev
. 2013 Dec;
114(1):233-54.
PMID: 24308533
No abstract available.
19.
Rastinejad F, Huang P, Chandra V, Khorasanizadeh S
J Mol Endocrinol
. 2013 Oct;
51(3):T1-T21.
PMID: 24103914
Nuclear receptors (NRs) are a major transcription factor family whose members selectively bind small-molecule lipophilic ligands and transduce those signals into specific changes in gene programs. For over two decades,...
20.
Huh J, Englund E, Wang H, Huang R, Huang P, Rastinejad F, et al.
ACS Med Chem Lett
. 2013 Sep;
4(1):79-84.
PMID: 24040486
Retinoic acid-related orphan receptor RORγt plays a pivotal role in the differentiation of T17 cells. Antagonizing RORγt transcriptional activity is a potential means to treat T17-related autoimmune diseases. Herein, we...