Pedro Aparicio
Overview
Explore the profile of Pedro Aparicio including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
353
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0
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Recent Articles
1.
Molina M, Garcia-Bernal D, Salinas M, Rubio G, Aparicio P, Moraleda J, et al.
Front Cell Dev Biol
. 2022 Apr;
10:797945.
PMID: 35419364
The lack of knowledge of the progression mechanisms of glioblastoma (GB), the most aggressive brain tumor, contributes to the absence of successful therapeutic strategies. Our team has recently demonstrated a...
2.
Galindo-Campos M, Bedora-Faure M, Farres J, Lescale C, Moreno-Lama L, Martinez C, et al.
Cell Death Differ
. 2019 Apr;
26(12):2667-2681.
PMID: 30996287
Poly (ADP-ribose) polymerase (PARP)-1 and PARP-2 regulate the function of various DNA-interacting proteins by transferring ADP-ribose emerging from catalytic cleavage of cellular β-NAD. Hence, mice lacking PARP-1 or PARP-2 show...
3.
Baroja-Mazo A, Revilla-Nuin B, de Bejar A, Martinez-Alarcon L, Herrero J, El-Tayeb A, et al.
Am J Transplant
. 2018 Jul;
19(1):48-61.
PMID: 30019408
The artificial induction of tolerance in transplantation is gaining strength. In mice, a differential role of extracellular adenosine (eADO) for regulatory and effector T cells (Tregs and Teffs, respectively) has...
4.
Navarro J, Gozalbo-Lopez B, Mendez A, Dantzer F, Schreiber V, Martinez C, et al.
Sci Rep
. 2017 Feb;
7:41962.
PMID: 28181505
The maintenance of T-cell homeostasis must be tightly regulated. Here, we have identified a coordinated role of Poly(ADP-ribose) polymerase-1 (PARP-1) and PARP-2 in maintaining T-lymphocyte number and function. Mice bearing...
5.
Aparicio P, Thompson M, Watton P
J Biomech
. 2016 May;
49(12):2321-30.
PMID: 27184922
Arterial growth and remodelling (G&R) is mediated by vascular cells in response to their chemical and mechanical environment. To date, mechanical and biochemical stimuli tend to be modelled separately, however...
6.
Martinez-Florensa M, Garcia-Blesa A, Yelamos J, Munoz-Suano A, Dominguez-Villar M, Valdor R, et al.
J Leukoc Biol
. 2010 Oct;
89(1):63-73.
PMID: 20940326
The adaptor protein LAT has a prominent role in the transduction of intracellular signals elicited by the TCR/CD3 complex. Upon TCR engagement, LAT becomes tyrosine-phosphorylated and thereby, recruits to the...
7.
Pons J, Revilla-Nuin B, Baroja-Mazo A, Ramirez P, Martinez-Alarcon L, Sanchez-Bueno F, et al.
Transplantation
. 2008 Nov;
86(10):1370-8.
PMID: 19034005
Background: Human liver allografts do sometimes survive in a recipient after withdrawal of immunosuppression (IS), commonly referred to as "operational tolerance." Preliminary clinical data have suggested an increase in the...
8.
Saenz L, Lozano J, Valdor R, Baroja-Mazo A, Ramirez P, Parrilla P, et al.
BMC Genomics
. 2008 Apr;
9:171.
PMID: 18412984
Background: Accumulating evidence suggests an important role for the enzyme poly(ADP-ribose) polymerase-1 (PARP-1) as an integral part of the gene expression regulatory machinery during development and in response to specific...
9.
Aguado E, Martinez-Florensa M, Aparicio P
Transpl Immunol
. 2006 Dec;
17(1):23-6.
PMID: 17157209
The adapter molecule LAT (Linker for the Activation of T cells) is a membrane protein that becomes phosphorylated on conserved tyrosine residues upon TCR/CD3 complex engagement in T lymphocytes. Tyrosine...
10.
Yelamos J, Monreal Y, Saenz L, Aguado E, Schreiber V, Mota R, et al.
EMBO J
. 2006 Sep;
25(18):4350-60.
PMID: 16946705
Poly-(ADP-ribose) polymerase-2 (PARP-2) belongs to a large family of enzymes that synthesize and transfer ADP-ribose polymers to acceptor proteins, modifying their functional properties. PARP-2-deficient (Parp-2-/-) cells, similar to Parp-1-/- cells,...