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Pavol Kosik

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Articles 15
Citations 118
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Recent Articles
1.
Vrobelova K, Jakl L, Skorvaga M, Kosik P, Durdik M, Markova E, et al.
Sci Rep . 2025 Mar; 15(1):8953. PMID: 40089517
Preleukemic stem cells (PSC) containing preleukemic fusion genes (PFG) arise prenatally and represent the initial stage of acute lymphoblastic leukemia (ALL) development. Despite widespread efforts, the cell of origin of...
2.
Vinnikov V, Kochanova D, Vigasova K, Gulati S, Durdik M, Kosik P, et al.
Mutat Res Genet Toxicol Environ Mutagen . 2025 Mar; 902:503849. PMID: 40044372
Cytogenetic biodosimetry relies on dose-response curves (DRCs) for each type of radiation that can cause a radiation emergency. We have constructed a DRC based on the dicentric assay. Blood samples...
3.
Gulati S, Mosgoeller W, Moldan D, Kosik P, Durdik M, Jakl L, et al.
Ecotoxicol Environ Saf . 2024 May; 279:116486. PMID: 38820877
Human exposure to radiofrequency electromagnetic fields (RF-EMF) is restricted to prevent thermal effects in the tissue. However, at very low intensity exposure "non-thermal" biological effects, like oxidative stress, DNA or...
4.
Kochanova D, Gulati S, Durdik M, Jakl L, Kosik P, Skorvaga M, et al.
Sci Rep . 2023 Sep; 13(1):15525. PMID: 37726322
Interventional radiologists are chronically exposed to low-dose ionizing radiation (IR), which may represent a health risk. The aim of the present study was to evaluate genomic instability by analyzing chromosomal...
5.
Durdik M, Markova E, Kosik P, Vigasova K, Gulati S, Jakl L, et al.
Biomedicines . 2023 May; 11(4). PMID: 37189740
About 5% of patients undergoing radiotherapy (RT) develop RT-related side effects. To assess individual radiosensitivity, we collected peripheral blood from breast cancer patients before, during and after the RT, and...
6.
Kosik P, Skorvaga M, Belyaev I
Int J Mol Sci . 2023 Apr; 24(7). PMID: 37047553
Although the prevalence of leukemia is increasing, the agents responsible for this increase are not definitely known. While ionizing radiation (IR) was classified as a group one carcinogen by the...
7.
Durdik M, Kosik P, Jakl L, Kozackova M, Markova E, Vigasova K, et al.
Cytometry A . 2021 Jun; 99(12):1198-1208. PMID: 34089242
DNA double strand breaks (DSB) induced by ionizing radiation (IR) are usually measured using γH2AX/53BP1 DNA repair foci, that is considered to be the most sensitive assay for DSB analysis....
8.
Kosik P, Durdik M, Skorvaga M, Klimova D, Kochanova D, Cerna Z, et al.
Antioxidants (Basel) . 2021 Apr; 10(3). PMID: 33803739
Preleukemic fusion genes (PFGs) occurring after DNA damage in hematopoietic stem progenitor cells (HSPCs) in utero often represent the initial event in the development of childhood leukemia. While the incidence...
9.
Gulati S, Kosik P, Durdik M, Skorvaga M, Jakl L, Markova E, et al.
Environ Pollut . 2020 Dec; 267:115632. PMID: 33254645
Different scientific reports suggested link between exposure to radiofrequency radiation (RF) from mobile communications and induction of reactive oxygen species (ROS) and DNA damage while other studies have not found...
10.
Kosik P, Durdik M, Jakl L, Skorvaga M, Markova E, Vesela G, et al.
Sci Rep . 2020 Aug; 10(1):13722. PMID: 32839487
There is clear evidence that ionizing radiation (IR) causes leukemia. For many types of leukemia, the preleukemic fusion genes (PFG), as consequences of DNA damage and chromosomal translocations, occur in...