Pauline J Schipper
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Explore the profile of Pauline J Schipper including associated specialties, affiliations and a list of published articles.
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10
Citations
123
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Recent Articles
1.
Gumbs S, Stam A, Mudrikova T, Schipper P, Hoepelman A, van Ham P, et al.
J Neurovirol
. 2024 May;
30(4):380-392.
PMID: 38713307
Despite antiretroviral therapy (ART), HIV persistence in the central nervous system (CNS) continues to cause a range of cognitive impairments in people living with HIV (PLWH). Upon disease progression, transmigrating...
2.
Zhang X, Wasserberg D, Breukers C, Connell B, Schipper P, van Dalum J, et al.
RSC Adv
. 2022 May;
10(31):18062-18072.
PMID: 35517228
On-chip sample preparation in self-contained microfluidic devices is a key element to realize simple, low-cost, yet reliable diagnostics that can be carried out at the point-of-care (POC) with minimal training...
3.
Gumbs S, Berdenis van Berlekom A, Kubler R, Schipper P, Gharu L, Boks M, et al.
Viruses
. 2022 Apr;
14(4).
PMID: 35458559
The achievement of an HIV cure is dependent on the eradication or permanent silencing of HIV-latent viral reservoirs, including the understudied central nervous system (CNS) reservoir. This requires a deep...
4.
Gumbs S, Kubler R, Gharu L, Schipper P, Borst A, Snijders G, et al.
J Neurovirol
. 2022 Feb;
28(1):64-91.
PMID: 35138593
HIV persistence in the CNS despite antiretroviral therapy may cause neurological disorders and poses a critical challenge for HIV cure. Understanding the pathobiology of HIV-infected microglia, the main viral CNS...
5.
Connell B, Hermans L, Wensing A, Schellens I, Schipper P, van Ham P, et al.
Sci Rep
. 2020 Sep;
10(1):15866.
PMID: 32985522
HIV-1 cell entry is mediated by binding to the CD4-receptor and chemokine co-receptors CCR5 (R5) or CXCR4 (X4). R5-tropic viruses are predominantly detected during early infection. A switch to X4-tropism...
6.
Fun A, Leitner T, Vandekerckhove L, Daumer M, Thielen A, Buchholz B, et al.
Retrovirology
. 2018 Jan;
15(1):1.
PMID: 29304821
Background: Emergence of resistance against integrase inhibitor raltegravir in human immunodeficiency virus type 1 (HIV-1) patients is generally associated with selection of one of three signature mutations: Y143C/R, Q148K/H/R or...
7.
van Maarseveen N, Andersson D, Lepsik M, Fun A, Schipper P, De Jong D, et al.
Retrovirology
. 2012 Apr;
9:29.
PMID: 22462820
Background: Mutations in the substrate of HIV-1 protease, especially changes in the NC/p1 cleavage site, can directly contribute to protease inhibitor (PI) resistance and also compensate for defects in viral...
8.
Fun A, van Maarseveen N, Pokorna J, Maas R, Schipper P, Konvalinka J, et al.
Retrovirology
. 2011 Aug;
8:70.
PMID: 21864346
Background: Maturation inhibitors are an experimental class of antiretrovirals that inhibit Human Immunodeficiency Virus (HIV) particle maturation, the structural rearrangement required to form infectious virus particles. This rearrangement is triggered...
9.
Fun A, Van Baelen K, Van Lelyveld S, Schipper P, Stuyver L, Wensing A, et al.
J Antimicrob Chemother
. 2010 Aug;
65(11):2300-4.
PMID: 20736234
Objectives: The genetic barrier to development of raltegravir resistance is considered to be low, requiring at least one primary integrase mutation: Y143C, Q148H/K/R or N155H to confer raltegravir therapy failure....
10.
van Elden L, Sachs A, van Loon A, Haarman M, van de Vijver D, Kimman T, et al.
J Clin Virol
. 2007 Dec;
41(2):116-21.
PMID: 18096430
Background: Viral respiratory infections, particularly human rhinovirus (HRV) infections, are the most common cause of asthma exacerbation. HRV infections usually lead to more severe and longer duration of lower respiratory...