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Pauline A M Roest

Explore the profile of Pauline A M Roest including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 3
Citations 61
Followers 0
Related Specialty
Endocrinology
Top 10 Co-Authors
Adriana C Gittenberger-de Groot
Ulf J Eriksson
Daniel G M Molin
Liesbeth Van Iperen
Lambertus J Wisse
Robert E Poelmann
Rob E Poelmann
Casper G Schalkwijk
Regine P M Steegers-Theunissen
Parri Wentzel
Published In
Birth Defects Res A Clin Mol Teratol
Diabetes
Affiliations
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Recent Articles
1.
Specific local cardiovascular changes of Nepsilon-(carboxymethyl)lysine, vascular endothelial growth factor, and Smad2 in the developing embryos coincide with maternal diabetes-induced congenital heart defects
Roest P, Molin D, Schalkwijk C, Van Iperen L, Wentzel P, Eriksson U, et al.
Diabetes . 2009 Feb; 58(5):1222-8. PMID: 19188426
Objective: Embryos exposed to a diabetic environment in utero have an increased risk to develop congenital heart malformations. The mechanism behind the teratogenicity of diabetes still remains enigmatic. Detrimental effects...
2.
Exposure of neural crest cells to elevated glucose leads to congenital heart defects, an effect that can be prevented by N-acetylcysteine
Roest P, Van Iperen L, Vis S, Wisse L, Poelmann R, Steegers-Theunissen R, et al.
Birth Defects Res A Clin Mol Teratol . 2006 Dec; 79(3):231-5. PMID: 17183584
Background: Diabetes mellitus during pregnancy increases the risk for congenital heart disease in the offspring. The majority of the cardiovascular malformations occur in the outflow tract and pharyngeal arch arteries,...
3.
Disturbed morphogenesis of cardiac outflow tract and increased rate of aortic arch anomalies in the offspring of diabetic rats
Molin D, Roest P, Nordstrand H, Wisse L, Poelmann R, Eriksson U, et al.
Birth Defects Res A Clin Mol Teratol . 2004 Dec; 70(12):927-38. PMID: 15578651
Background: Maternal diabetes (MD) is a risk factor for offspring to develop cardiovascular anomalies; this is of growing clinical concern since the number of women in childbearing age with compromised...