Paula L Jacobsen
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Explore the profile of Paula L Jacobsen including associated specialties, affiliations and a list of published articles.
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16
Citations
355
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Recent Articles
1.
Thase M, Jacobsen P, Hanson E, Xu R, Tolkoff M, Murthy N
J Affect Disord
. 2022 Feb;
303:123-130.
PMID: 35131363
Background: Maintenance therapy for major depressive disorder (MDD) is typically recommended at the dose on which the patient was stabilized. However, for some patients, dose alteration may be required. We...
2.
Mahableshwarkar A, Affinito J, Reines E, Xu J, Nomikos G, Jacobsen P
CNS Spectr
. 2019 Jun;
25(3):352-362.
PMID: 31199210
Objectives: This study aimed to evaluate the risk of suicidal ideation and behavior associated with vortioxetine treatment in adults with major depressive disorder (MDD). Methods: Suicide-related events were evaluated post...
3.
Jacobsen P, Nomikos G, Zhong W, Cutler A, Affinito J, Clayton A
CNS Spectr
. 2019 Apr;
25(1):50-63.
PMID: 31010445
Objective: The objective of this work was to describe treatment-emergent sexual dysfunction (TESD) and tolerability following a switch from selective serotonin reuptake inhibitor (SSRI: citalopram, paroxetine, or sertraline) monotherapy to...
4.
Thase M, Danchenko N, Brignone M, Florea I, Diamand F, Jacobsen P, et al.
Eur Neuropsychopharmacol
. 2017 Jul;
27(8):773-781.
PMID: 28663124
Switching antidepressant therapy is a recommended strategy for depressed patients who neither respond to nor tolerate an initial pharmacotherapy course. This paper reviews the efficacy and tolerability of switching to...
5.
The effect of vortioxetine on overall patient functioning in patients with major depressive disorder
Florea I, Loft H, Danchenko N, Rive B, Brignone M, Merikle E, et al.
Brain Behav
. 2017 Mar;
7(3):e00622.
PMID: 28293465
Background: The objectives of this meta-analysis of data from randomized, placebo-controlled studies were to assess the effect of vortioxetine on overall functioning (primary) and functional remission (secondary) using the Sheehan...
6.
Baldwin D, Florea I, Jacobsen P, Zhong W, Nomikos G
J Affect Disord
. 2016 Jul;
206:140-150.
PMID: 27474960
Background: Coexisting anxiety is common in major depressive disorder (MDD) and more difficult to treat than depression without anxiety. This analysis assessed the efficacy, safety, and tolerability of vortioxetine in...
7.
Jacobsen P, Mahableshwarkar A, Palo W, Chen Y, Dragheim M, Clayton A
CNS Spectr
. 2015 Nov;
21(5):367-378.
PMID: 26575433
Objective: Antidepressants are frequently associated with treatment-emergent sexual dysfunction (TESD). Vortioxetine, which was approved for patients with major depressive disorder (MDD), has a receptor profile that suggests limited impact on...
8.
Jacobsen P, Mahableshwarkar A, Chen Y, Chrones L, Clayton A
J Sex Med
. 2015 Sep;
12(10):2036-48.
PMID: 26331383
Introduction: Sexual dysfunction is common with serotonergic antidepressants, including selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), and does not resolve in most patients. Vortioxetine, an antidepressant with...
9.
Mahableshwarkar A, Jacobsen P, Serenko M, Chen Y, Trivedi M
J Clin Psychiatry
. 2015 Jun;
76(5):583-91.
PMID: 26035186
Background: This 8-week, randomized, double-blind, placebo-controlled study, conducted August 2010-May 2012 in the United States, evaluated the safety and efficacy of vortioxetine 10 mg and 15 mg in patients with...
10.
Jacobsen P, Mahableshwarkar A, Serenko M, Chan S, Trivedi M
J Clin Psychiatry
. 2015 Jun;
76(5):575-82.
PMID: 26035185
Context: Vortioxetine (Lu AA21004) is an antidepressant with a mechanism of action thought to be related to a combination of 2 pharmacologic actions: direct modulation of several receptors and inhibition...