Paula Carpintero-Fernandez
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Explore the profile of Paula Carpintero-Fernandez including associated specialties, affiliations and a list of published articles.
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15
Citations
397
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Recent Articles
1.
Carpintero-Fernandez P, Varela-Eirin M, Garcia-Yuste A, Lopez-Diaz I, Caeiro J, Mayan M
Bioelectricity
. 2024 Oct;
4(1):39-47.
PMID: 39355566
Osteoarthritis (OA) is the most common joint disease. In the last years, the research community has focused on understanding the molecular mechanisms that led to the pathogenesis of the disease,...
2.
Rodriguez-Candela Mateos M, Carpintero-Fernandez P, Freijanes P, Mosquera J, Nebril B, Mayan M
Biochim Biophys Acta Rev Cancer
. 2024 Aug;
1879(5):189173.
PMID: 39154967
Gap junctions, membrane-based channels comprised of connexin proteins (Cxs), facilitate direct communication among neighbouring cells and between cells and the extracellular space through their hemichannels. The normal human breast expresses...
3.
Diez-Villares S, Garcia-Varela L, Antas S, Caeiro J, Carpintero-Fernandez P, Mayan M, et al.
J Control Release
. 2023 Mar;
356:702-713.
PMID: 36931471
Intra-articular (IA) administration of drugs for the treatment of diseases such as rheumatoid arthritis, osteoarthritis and psoriatic arthritis is a common strategy; however, the rapid clearance from the synovial fluid...
4.
Varela-Eirin M, Carpintero-Fernandez P, Guitian-Caamano A, Varela-Vazquez A, Garcia-Yuste A, Sanchez-Temprano A, et al.
Cell Death Dis
. 2022 Aug;
13(8):681.
PMID: 35931686
The accumulation of senescent cells is a key characteristic of aging, leading to the progression of age-related diseases such as osteoarthritis (OA). Previous data from our laboratory has demonstrated that...
5.
Carpintero-Fernandez P, Borghesan M, Eleftheriadou O, Pan-Castillo B, Fafian-Labora J, Mitchell T, et al.
Cell Death Dis
. 2022 Feb;
13(2):163.
PMID: 35184131
During this last decade, the development of prosenescence therapies has become an attractive strategy as cellular senescence acts as a barrier against tumour progression. In this context, CDK4/6 inhibitors induce...
6.
Varela-Eirin M, Carpintero-Fernandez P, Sanchez-Temprano A, Varela-Vazquez A, Paino C, Casado-Diaz A, et al.
Aging (Albany NY)
. 2020 Aug;
12(16):15882-15905.
PMID: 32745074
Articular cartilage and synovial tissue from patients with osteoarthritis (OA) show an overactivity of connexin43 (Cx43) and accumulation of senescent cells associated with disrupted tissue regeneration and disease progression. The...
7.
Varela-Vazquez A, Guitian-Caamano A, Carpintero-Fernandez P, Fonseca E, Sayedyahossein S, Aasen T, et al.
Biochim Biophys Acta Rev Cancer
. 2020 May;
1874(1):188380.
PMID: 32461135
Cellular communication through gap junctions and hemichannels formed by connexins and through channels made by pannexins allows for metabolic cooperation and control of cellular activity and signalling. These channel proteins...
8.
Carpintero-Fernandez P, Varela-Eirin M, Lacetera A, Gago-Fuentes R, Fonseca E, Martin-Santamaria S, et al.
Biomolecules
. 2020 Apr;
10(4).
PMID: 32326143
Osteoarthritis (OA) is the most common degenerative joint disease characterized by articular cartilage degradation and joint degeneration. The articular cartilage is mainly formed by chondrocytes and a collagen-proteoglycan extracellular matrix...
9.
Borghesan M, Fafian-Labora J, Eleftheriadou O, Carpintero-Fernandez P, Paez-Ribes M, Vizcay-Barrena G, et al.
Cell Rep
. 2019 Jun;
27(13):3956-3971.e6.
PMID: 31242426
Senescence is a cellular phenotype present in health and disease, characterized by a stable cell-cycle arrest and an inflammatory response called senescence-associated secretory phenotype (SASP). The SASP is important in...
10.
Fafian-Labora J, Carpintero-Fernandez P, Jordan S, Shikh-Bahaei T, Abdullah S, Mahenthiran M, et al.
Cell Death Dis
. 2019 Apr;
10(4):318.
PMID: 30962418
Senescent cells accumulate in several tissues during ageing and contribute to several pathological processes such as ageing and cancer. Senescence induction is a complex process not well defined yet and...