Paul Zeun
Overview
Explore the profile of Paul Zeun including associated specialties, affiliations and a list of published articles.
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12
Citations
192
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0
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Recent Articles
1.
Hassan Y, Rodrigues F, Zeun P, Byrne L, Estevez-Fraga C, Tortelli R, et al.
Sci Rep
. 2022 Nov;
12(1):18377.
PMID: 36319718
Lumbar puncture (LP) has become increasingly common for people with Huntington's disease (HD) both to administer intrathecal investigational medicinal products and to collect cerebrospinal fluid to develop biological markers to...
2.
McColgan P, Gregory S, Zeun P, Zarkali A, Johnson E, Parker C, et al.
Brain
. 2022 Jun;
145(11):3953-3967.
PMID: 35758263
Upregulation of functional network connectivity in the presence of structural degeneration is seen in the premanifest stages of Huntington's disease (preHD) 10-15 years from clinical diagnosis. However, whether widespread network...
3.
Zeun P, McColgan P, Dhollander T, Gregory S, Johnson E, Papoutsi M, et al.
Neuroimage Clin
. 2022 Jan;
33:102927.
PMID: 34999565
Objectives: To investigate the timeframe prior to symptom onset when cortico-basal ganglia white matter (white matter) loss begins in premanifest Huntington's disease (preHD), and which striatal and thalamic sub-region white...
4.
Nair A, Johnson E, Gregory S, Osborne-Crowley K, Zeun P, Scahill R, et al.
Biol Psychiatry Cogn Neurosci Neuroimaging
. 2021 Apr;
6(9):910-918.
PMID: 33795209
Background: In this study, we asked whether differences in striatal activity during a reinforcement learning (RL) task with gain and loss domains could be one of the earliest functional imaging...
5.
Johnson E, Parker C, Scahill R, Gregory S, Papoutsi M, Zeun P, et al.
EBioMedicine
. 2021 Mar;
65:103266.
PMID: 33706250
Background: Pathological processes in Huntington's disease (HD) begin many years prior to symptom onset. Recently we demonstrated that in a premanifest cohort approximately 24 years from predicted disease onset, despite...
6.
Langley C, Gregory S, Osborne-Crowley K, OCallaghan C, Zeun P, Lowe J, et al.
J Neurol Neurosurg Psychiatry
. 2020 Nov;
92(2):143-149.
PMID: 33130575
Objectives: Cognitive flexibility, which is key for adaptive decision-making, engages prefrontal cortex (PFC)-striatal circuitry and is impaired in both manifest and premanifest Huntington's disease (pre-HD). The aim of this study...
7.
Scahill R, Zeun P, Osborne-Crowley K, Johnson E, Gregory S, Parker C, et al.
Lancet Neurol
. 2020 May;
19(6):502-512.
PMID: 32470422
Background: Disease-modifying treatments are in development for Huntington's disease; crucial to their success is to identify a timepoint in a patient's life when there is a measurable biomarker of early...
8.
Zeun P, Scahill R, Tabrizi S, Wild E
Mol Cell Neurosci
. 2019 Feb;
97:67-80.
PMID: 30807825
Huntington's disease is a chronic progressive neurodegenerative condition for which there is no disease-modifying treatment. The known genetic cause of Huntington's disease makes it possible to identify individuals destined to...
9.
Estevez-Fraga C, Zeun P, Lopez-Sendon Moreno J
Drugs Aging
. 2018 Oct;
35(11):959-971.
PMID: 30357723
Drug-induced parkinsonism (DIP) and tardive dyskinesia (TD) are iatrogenic consequences of antidopaminergic drugs. Both are particularly prevalent among the elderly and those with dementia. However, despite their prevalence, these disorders...
10.
Zeun P, Gooday C, Nunney I, Dhatariya K
Int J Low Extrem Wounds
. 2015 Aug;
15(1):19-25.
PMID: 26315897
The optimal way to manage diabetic foot osteomyelitis remains uncertain, with debate in the literature as to whether it should be managed conservatively (ie, nonsurgically) or surgically. We aimed to...