Paul S Knoepfler
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Explore the profile of Paul S Knoepfler including associated specialties, affiliations and a list of published articles.
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2713
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Recent Articles
1.
Barlevy D, Juengst E, Kahn J, Moreno J, Lambert L, Charo A, et al.
Sci Public Policy
. 2024 Jul;
51(4):680-691.
PMID: 39035203
In response to calls for public engagement on human genome editing (HGE), which intensified after the 2018 He Jiankui scandal that resulted in the implantation of genetically modified embryos, we...
2.
Balashova O, Panoutsopoulos A, Visina O, Selhub J, Knoepfler P, Borodinsky L
Nat Commun
. 2024 Feb;
15(1):1642.
PMID: 38388461
Folate supplementation reduces the occurrence of neural tube defects (NTDs), birth defects consisting in the failure of the neural tube to form and close. The mechanisms underlying NTDs and their...
3.
Klein R, Knoepfler P
Epigenetics Chromatin
. 2023 Oct;
16(1):38.
PMID: 37814296
Histone variant H3.3 plays novel roles in development as compared to canonical H3 proteins and is the most commonly mutated histone protein of any kind in human disease. Here we...
4.
Balashova O, Panoutsopoulos A, Visina O, Selhub J, Knoepfler P, Borodinsky L
bioRxiv
. 2023 Jul;
PMID: 37503108
Folate supplementation reduces the occurrence of neural tube defects, one of the most common and serious birth defects, consisting in the failure of the neural tube to form and close...
5.
Bush K, Cervantes V, Yee J, Klein R, Knoepfler P
Genesis
. 2023 Jan;
61(1-2):e23507.
PMID: 36656301
Histone variant H3.3 is encoded by two genes, H3f3a and H3f3b, which can be expressed differentially depending on tissue type. Previous work in our lab has shown that knockout of...
6.
Lewis N, Klein R, Kelly C, Yee J, Knoepfler P
Epigenetics Chromatin
. 2022 May;
15(1):18.
PMID: 35590427
Background: The histone variant H3.3 K27M mutation is a defining characteristic of diffuse intrinsic pontine glioma (DIPG)/diffuse midline glioma (DMG). This histone mutation is responsible for major alterations to histone...
7.
Hishida T, Vazquez-Ferrer E, Hishida-Nozaki Y, Takemoto Y, Hatanaka F, Yoshida K, et al.
Front Cell Dev Biol
. 2022 Mar;
10:786031.
PMID: 35309931
It is widely believed that cellular senescence plays a critical role in both aging and cancer, and that senescence is a fundamental, permanent growth arrest that somatic cells cannot avoid....
8.
Klein R, Knoepfler P
Stem Cell Reports
. 2021 Nov;
16(12):2844-2851.
PMID: 34767751
Many gene networks are shared between pluripotent stem cells and cancer; a concept exemplified by several DPPA factors such as DPPA2 and DPPA4, which are highly and selectively expressed in...
9.
Kim M, Knoepfler P
Regen Med
. 2021 Jun;
16(6):525-533.
PMID: 34114493
There is a critical need for safe and effective treatments for COVID-19. One possible type of treatment is cellular medicine such as stem cell therapy, but its potential is unclear....
10.
Klein R, Knoepfler P
Cell Stem Cell
. 2021 May;
28(5):785-787.
PMID: 33961758
In this issue of Cell Stem Cell, Funato et al. (2021) and Bressan et al. (2021) use stem cells as models to define functions of the histone H3.3 G34R mutation...